OncoMatch/Clinical Trials/NCT07069712

A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma

Is NCT07069712 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for gastroesophageal adenocarcinoma.

Phase 2RecruitingAstraZenecaNCT07069712Data as of May 2026

Treatment: AZD0901 · Rilvegostomig · Trastuzumab Deruxtecan (T-DXd) · Capecitabine · 5-Fluorouracil (5-FU) · FLOT Chemotherapy — GEMINI-PeriOp GC study will assess the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity of novel agents or novel combinations as perioperative treatment in participants with locally advanced resectable gastric, gastroesophageal junction (GEJ), or esophageal adenocarcinoma who have not received previous treatment for the disease.

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Extracted eligibility criteria

Cancer type

Gastric Cancer

Esophageal Carcinoma

Biomarker criteria

Required: CLDN18 overexpression (positive)

CLDN18.2-positive

Required: HER2 (ERBB2) wild-type

HER2-negative

Required: HER2 (ERBB2) overexpression (positive)

HER2-positive

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)

Max 0 prior lines

Cannot have received: any anti-cancer treatment or surgery for current gastric, GEJ, or esophageal cancer

Participants had any prior anti-cancer treatment or surgery for the current gastric, GEJ, or esophageal cancer.

Lab requirements

Blood counts

adequate organ and bone marrow function

Kidney function

adequate organ and bone marrow function

Liver function

adequate organ and bone marrow function

Adequate organ and bone marrow function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

Research Site · Newark, Delaware
Research Site · Washington D.C., District of Columbia
Research Site · Fairway, Kansas
Research Site · North Shores, Michigan
Research Site · New York, New York

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