OncoMatch/Clinical Trials/NCT07069699
Testing the Safety of Anti-Cancer Drug, CX-5461 (Pidnarulex), in Treating Lymphoma With Specific Changes in the MYC Gene
Is NCT07069699 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies Pidnarulex for burkitt lymphoma.
Treatment: Pidnarulex — This phase Ib/II trial tests the safety, side effects, best dose and how well giving CX-5461 works for the treatment of patients with B-cell non-Hodgkin lymphoma. CX-5461 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving CX-5461 may be safe, tolerable and/or effective in treating patients with B-cell non-Hodgkin lymphoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Biomarker criteria
Required: BCL2 rearrangement
Required: BCL6 rearrangement
Required: MYC rearrangement
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Lab requirements
Blood counts
Absolute neutrophil count ≥ 1,000/mcL; Platelets ≥ 50,000/mcL
Kidney function
GFR ≥ 60 mL/min, calculated by eGFR × BSA / 1.73 m^2
Liver function
Total bilirubin ≤ 1.5 institutional ULN (≤ 3 × ULN if Gilbert's syndrome and direct bilirubin normal); AST/ALT ≤ 3 × ULN
Cardiac function
NYHA class II or better; baseline QTc ≤ 480 msec
Absolute neutrophil count ≥ 1,000/mcL; Platelets ≥ 50,000/mcL; Total bilirubin ≤ 1.5 institutional ULN (≤ 3 × ULN if Gilbert's syndrome and direct bilirubin normal); AST/ALT ≤ 3 × ULN; GFR ≥ 60 mL/min, calculated by eGFR × BSA / 1.73 m^2; NYHA class II or better; baseline QTc ≤ 480 msec
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Yale University Cancer Center LAO · New Haven, Connecticut
- University of Oklahoma Health Sciences Center · Oklahoma City, Oklahoma
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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