OncoMatch/Clinical Trials/NCT07068607
Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial
Is NCT07068607 recruiting? Yes, currently enrolling (May 2026). This Phase 4 trial studies multiple treatments for gastritis, indigestion, helicobacter pylori infection, gastric cancer, peptic ulcer.
Treatment: Vonoprazan · Tetracycline 500mg tid · Minocycline · Bismuth · Clarithromycin 500 mg · Amoxicillin — This study aims to evaluate the efficacy of vonoprazan combined with different antibiotics in dual therapy for Helicobacter pylori eradication treatment. Newly infected patients were randomly assigned to four groups: amoxicillin dual therapy, tetracycline dual therapy, minocycline dual therapy, and bismuth quadruple therapy. At the follow - up visit in the 6th week, urea breath test, rapid urease test, or Helicobacter pylori fecal antigen test will be conducted to confirm eradication.
Check if I qualifyExtracted eligibility criteria
Cancer type
Gastric Cancer
Prior therapy
Cannot have received: Helicobacter pylori eradication treatment
Patients who have been definitely diagnosed with Hp infection and have received antibiotic eradication treatment
Cannot have received: anti-ulcer drugs (proton pump inhibitor)
Exception: PPI within 2 weeks before the Hp infection test
Patients who have been continuously using anti-ulcer drugs (including taking PPI within 2 weeks before the Hp infection test), antibiotics or bismuth complexes (more than 3 times a week within 1 month before screening)
Cannot have received: antibiotics
Exception: more than 3 times a week within 1 month before screening
Patients who have been continuously using anti-ulcer drugs (including taking PPI within 2 weeks before the Hp infection test), antibiotics or bismuth complexes (more than 3 times a week within 1 month before screening)
Cannot have received: bismuth complexes
Exception: more than 3 times a week within 1 month before screening
Patients who have been continuously using anti-ulcer drugs (including taking PPI within 2 weeks before the Hp infection test), antibiotics or bismuth complexes (more than 3 times a week within 1 month before screening)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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