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OncoMatch/Clinical Trials/NCT07066657

A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors

Is NCT07066657 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies MRG007 for locally advanced or metastatic solid tumors.

Phase 1RecruitingArriVent BioPharma, Inc.NCT07066657Data as of May 2026

Treatment: MRG007This is an open-label, multi-center, phase I study to evaluate the safety, tolerability, efficacy, and pharmacokinetics of MRG007 (ARR-217) in patients with unresectable locally advanced or metastatic solid tumors.

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Extracted eligibility criteria

Cancer type

Tumor Agnostic

Colorectal Cancer

Gastric Cancer

Pancreatic Cancer

Biomarker criteria

Required: CDH17 any tested (testing required; no eligibility threshold specified)

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Cannot have received: CDH17-targeting anti-tumor therapy

Received CDH17-targeting anti-tumor therapy

Cannot have received: other investigational product

received other investigational product ... within 4 weeks prior to the first dose

Cannot have received: systemic corticosteroids

received ... systemic corticosteroids ... within 4 weeks prior to the first dose

Cannot have received: major organ surgery

surgery for major organs within 4 weeks prior to the first dose

Cannot have received: anti-tumor therapy

received anti-tumor therapy within 3 weeks or within 5 half-lives prior to the first dose, whichever is shorter

Cannot have received: radiotherapy

received radiotherapy within 2 weeks prior to the first dose

Lab requirements

Blood counts

Organ functions and coagulation function must meet the basic requirements

Kidney function

Organ functions and coagulation function must meet the basic requirements

Liver function

Organ functions and coagulation function must meet the basic requirements

Organ functions and coagulation function must meet the basic requirements

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • ULCA · Los Angeles, California
  • UCSF · San Francisco, California
  • University of Colorado · Aurora, Colorado
  • Sarah Cannon Research Institute · Denver, Colorado
  • Sarah Cannon Research Institute · Sarasota, Florida

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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