OncoMatch/Clinical Trials/NCT07061704
Oncolytic Virus in Esophageal Squamous Cell Carcinoma
Is NCT07061704 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1/2 trial studies multiple treatments including Oncolytic Virus: Administered via intratumoral and Oncolytic Virus: Administered via intratumoral for esophageal cancer.
Treatment: Oncolytic Virus: Administered via intratumoral · Oncolytic Virus: Administered via intratumoral — This clinical trial is designed to evaluate the preliminary efficacy and safety of an oncolytic virus combined with chemotherapy and an immune checkpoint inhibitor in patients with initially unresectable, locally advanced esophageal squamous cell carcinoma (ESCC). The primary endpoints are safety, surgical conversion rate and event-free survival (EFS). Secondary endpoints include overall survival (OS), objective response rate (ORR), and quality of life (QoL). Exploratory endpoints include biomarker analyses such as single-cell sequencing.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Esophageal Carcinoma
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Cannot have received: antitumor chemotherapy
Received prior antitumor chemotherapy
Cannot have received: radiotherapy
Received prior radiotherapy
Cannot have received: immunotherapy
Received prior immunotherapy
Lab requirements
Blood counts
Normal major organ function
Kidney function
Normal major organ function
Liver function
Normal major organ function
Cardiac function
Normal major organ function
Normal major organ function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT07061704 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
Is there an age limit?
Yes. Patients must be 80 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages