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OncoMatch/Clinical Trials/NCT07038343

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

Is NCT07038343 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1/2 trial studies multiple treatments including AVZO-1418 and Combination Agent 1 for solid tumor cancer.

Phase 1/2RecruitingAvenzo Therapeutics, Inc.NCT07038343Data as of Jun 2026

Treatment: AVZO-1418 · Combination Agent 1 · Combination Agent 2This study, the first clinical trial of AVZO-1418, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-1418 when administered intravenously as a monotherapy and potentially in combination therapy to patients with locally advanced or metastatic epithelial solid tumors.

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Extracted eligibility criteria

Treatments studied

Other

AVZO-1418Combination Agent 1Combination Agent 2

Cancer type

Tumor Agnostic

Performance status

ECOG 0–1(Restricted strenuous activity)

Demographics

Ages ≤ 75

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Avenzo Therapeutics Recruiting Site · Gilbert, Arizona
  • Avenzo Therapeutics Recruiting Site · Los Angeles, California
  • Avenzo Therapeutics Recruiting Site · Denver, Colorado
  • Avenzo Therapeutics Recruiting Site · New Haven, Connecticut
  • Avenzo Therapeutics Recruiting Site · Washington D.C., District of Columbia

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Frequently asked questions

Is NCT07038343 currently recruiting?

Yes, this trial is currently recruiting patients.

Is there an age limit?

Yes. Patients must be 75 years or younger.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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