OncoMatch/Clinical Trials/NCT07018570
An Open Label Phase 2 Study of Total Neoadjuvant Therapy (TNT) Consisting of FLOT With Pembrolizumab and Short Radiation for Patients With Locally Advanced Gastroesophageal Junction Adenocarcinoma
Is NCT07018570 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for gastroesophageal junction (gej) adenocarcinoma.
Treatment: Pembrolizumab · Docetaxel · Oxaliplatin · Levofolinate · Fluorouracil (5-FU) — This study is to evaluate the effectiveness of treatment for esophagogastric junction carcinoma, total neoadjuvant therapy (TNT) including pembrolizumab and FLOT is conducted, aiming to choose between surgery or organ preservation treatment strategies.
Check if I qualifyExtracted eligibility criteria
Cancer type
Gastric Cancer
Esophageal Carcinoma
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: anti-pd-1/pd-l1/pd-l2 antibody
Lab requirements
Blood counts
Neutrophil count ≥1,500/mm3; Hemoglobin ≥9.0 g/dL; Platelet counts ≥100,000/mm3
Kidney function
Serum creatinine ≤1.5 mg/dL
Liver function
Total bilirubin ≤1.5 mg/dL; AST (GOT) ≤100 IU/L; ALT (GPT) ≤100 IU/L
Neutrophil count ≥1,500/mm3; Hemoglobin ≥9.0 g/dL; Platelet counts ≥100,000/mm3; Total bilirubin ≤1.5 mg/dL; AST (GOT) ≤100 IU/L; ALT (GPT) ≤100 IU/L; Serum creatinine ≤1.5 mg/dL
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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