OncoMatch/Clinical Trials/NCT07015892
Dose-Escalation Radiotherapy in Limited-Stage Small Cell Lung Cancer: A Phase III Randomized Trial
Is NCT07015892 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies non-drug interventions for small cell lung carcinoma.
This is a phase III clinical trial that aims to evaluate whether increasing the dose of radiotherapy given twice a day can improve treatment outcomes in patients with localized small cell lung cancer (SCLC). All patients will receive standard chemotherapy with cisplatin and etoposide and will be randomly assigned to one of three radiotherapy regimens. The main objective is to determine whether this intensified radiotherapy improves progression-free survival and overall survival. The study will also compare two different dose escalation strategies and assess treatment side effects and patients' quality of life. This research may help identify a more effective treatment approach for patients with limited-stage SCLC and could contribute to improving long-term survival in this aggressive type of cancer
Check if I qualifyExtracted eligibility criteria
Cancer type
Small Cell Lung Cancer
Disease stage
Required: Stage I, II, III
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: thoracic radiotherapy
No prior thoracic radiotherapy
Cannot have received: surgery for any lung cancer
Prior surgery or radiotherapy for any lung cancer (SCLC or NSCLC)
Cannot have received: radiotherapy for any lung cancer
Prior surgery or radiotherapy for any lung cancer (SCLC or NSCLC)
Lab requirements
Blood counts
wbc ≥3.0×10⁹/l, neutrophils ≥1.5×10⁹/l, platelets ≥100×10⁹/l, hemoglobin ≥90 g/l
Kidney function
creatinine normal or crcl ≥60 ml/min
Liver function
total bilirubin ≤1.5×uln, ast/alt ≤1.5×uln
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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