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OncoMatch/Clinical Trials/NCT07010263

A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy

Is NCT07010263 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies AK112 for small cell lung cancer.

Phase 3RecruitingAkesoNCT07010263Data as of May 2026

Treatment: AK112This is a randomized, double-blind, phase III clinical study to compare the efficacy and safety of AK112 to placebo as consolidation treatment for patients with limited stage small cell lung cancer who have not progressed following concurrent chemoradiation therapy.

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Extracted eligibility criteria

Cancer type

Small Cell Lung Cancer

Disease stage

Required: Stage I, II, III

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Must have received: concurrent chemoradiotherapy — limited-stage SCLC

Have Received concurrent chemoradiotherapy regimen as defined in protocol and have not progressed following concurrent chemoradiotherapy.

Cannot have received: systemic non-specific immunomodulatory therapy (interleukin, interferon, thymosin)

Prior treatments with systemic non-specific immunomodulatory therapy (such as interleukin, interferon, thymosin, etc.) within 2 weeks before the first administration of the study drugs.

Cannot have received: Chinese herbal medicine or traditional Chinese patent medicines with anti-tumor indications

Prior treatment with Chinese herbal medicine or traditional Chinese patent medicines with anti-tumor indications within 1 weeks before the first administration of the study drugs.

Cannot have received: immune mechanism-targeted therapy

Prior treatments targeting immune mechanisms, including, but not limited to, immune checkpoint inhibitors, immune checkpoint agonists, immune cell therapy.

Cannot have received: anti-angiogenic therapy

Prior treatments with anti-angiogenic therapy.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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