OncoMatch

OncoMatch/Clinical Trials/NCT06976476

Study of IgPro20 to Prevent Infection in People With Multiple Myeloma and Hypogammaglobulinemia

Is NCT06976476 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies IgPro20 for multiple myeloma.

Phase 2RecruitingMemorial Sloan Kettering Cancer CenterNCT06976476Data as of May 2026

Treatment: IgPro20 — The main purpose of this study is to see if IgPro20 can prevent infection in people with multiple myeloma (MM) who have hypogammaglobulinemia from receiving bispecific monoclonal antibodies (BsAbs).

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Extracted eligibility criteria

Cancer type

Multiple Myeloma

Performance status

ECOG 0–3(Limited self-care)

Prior therapy

Must have received: bispecific antibody

receiving a commercially available bispecific antibody

Cannot have received: hematopoietic stem cell transplant

Exception: within 3 months before enrollment

HSCT within 3 months before enrollment

Cannot have received: CAR-T cell therapy

Exception: planned in the next 6 months

Planned CAR-T therapy in the next 6 months

Cannot have received: IVIG

Exception: current or previous IVIG in the last 3 months

On current or previous IVIG (in the last 3 months)

Lab requirements

Blood counts

Neutrophils < 500 x 10^9 per mL, Platelets < 30 x 10^9 per mL excluded

Kidney function

Creatinine Cl <30 ml/min excluded

Neutrophils < 500 x 10^9 per mL, Platelets < 30 x 10^9 per mL; Creatinine Cl <30 ml/min

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Memorial Sloan Kettering Basking Ridge (All Protocol Activities) · Basking Ridge, New Jersey
  • Memorial Sloan Kettering Monmouth (All Protocol Activities) · Middletown, New Jersey
  • Memorial Sloan Kettering Bergen (All Protocol Activities) · Montvale, New Jersey
  • Memorial Sloan Kettering Suffolk-Commack (All Protocol Activity) · Commack, New York
  • Memorial Sloan Kettering Westchester (All Protocol Activities) · Harrison, New York

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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