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OncoMatch/Clinical Trials/NCT06961617

Autologous HBV-TCR T Cell Therapy (LioCyx-M) for the Treatment of Hepatocellular Carcinoma

Is NCT06961617 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies LioCyx-M, HBV antigen-specific TCR-redirected T cells for hepatocellular carcinoma.

Phase 1RecruitingLion TCR Pte. Ltd.NCT06961617Data as of May 2026

Treatment: LioCyx-M, HBV antigen-specific TCR-redirected T cellsThis is a single center and open-label study to determine the safety and efficacy of mRNA HBV-TCR redirected T-cells in HBV-related HCC who are not amenable to/failed conventional treatment.

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Extracted eligibility criteria

Cancer type

Hepatocellular Carcinoma

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Min 1 prior line

Must have received: systemic therapy

Lab requirements

Liver function

child-pugh a (5 - 7 points)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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