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OncoMatch/Clinical Trials/NCT06961617

Autologous HBV-TCR T Cell Therapy (LioCyx-M) for the Treatment of Hepatocellular Carcinoma

Is NCT06961617 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies LioCyx-M, HBV antigen-specific TCR-redirected T cells for hepatocellular carcinoma.

Phase 1RecruitingLion TCR Pte. Ltd.NCT06961617Data as of Jun 2026Location: China

Treatment: LioCyx-M, HBV antigen-specific TCR-redirected T cellsThis is a single center and open-label study to determine the safety and efficacy of mRNA HBV-TCR redirected T-cells in HBV-related HCC who are not amenable to/failed conventional treatment.

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Extracted eligibility criteria

Treatments studied

Other

LioCyx-M, HBV antigen-specific TCR-redirected T cells

Cancer type

Hepatocellular Carcinoma

Performance status

ECOG 0–1(Restricted strenuous activity)

Demographics

Ages ≤ 70

Prior therapy

Min 1 prior line

Must have received: systemic therapy

Lab requirements

Liver function

child-pugh a (5 - 7 points)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Frequently asked questions

Is NCT06961617 currently recruiting?

Yes, this trial is currently recruiting patients.

Is prior treatment required for enrollment?

Yes. Patients must have previously received systemic therapy.

Is there an age limit?

Yes. Patients must be 70 years or younger.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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