OncoMatch/Clinical Trials/NCT06959511
Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery
Is NCT06959511 recruiting? Yes, currently enrolling (Sep 2026). This Phase 2 trial studies Zanzalintinib for neoadjuvant treatment.
Treatment: Zanzalintinib — To look at the effectiveness of zanzalintinib, followed by surgery, in treating advanced thyroid cancer. The safety of this treatment will also be studied.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Targeted therapy
Cancer type
Thyroid Gland Carcinoma
Biomarker criteria
Excluded: RET mutation
Medullary thyroid cancer participants with germline RET or known somatic RET mutations
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: zanzalintinib
Prior treatment with zanzalintinib
Cannot have received: tyrosine kinase inhibitor
Prior treatment with a tyrosine kinase inhibitor
Lab requirements
Blood counts
ANC ≥ 1500/mm3 without G-CSF support; platelets ≥ 100,000/mm3 without transfusion; hemoglobin ≥ 9 g/dL without transfusion
Kidney function
Serum creatinine ≤ 1.5 x ULN or calculated creatinine clearance ≥ 40 mL/min
Liver function
ALT, AST, and ALP ≤ 3 x ULN (≤ 5 x ULN with bone metastasis); total bilirubin ≤ 1.5 x ULN (≤ 3 x ULN with Gilbert's disease)
Adequate organ and marrow function, based upon meeting all the following laboratory criteria within 28 days before first dose of study treatment
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Cleveland Clinic Taussig Cancer Institute · Cleveland, Ohio
- MD Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT06959511 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior zanzalintinib, tyrosine kinase inhibitor disqualifies patients from enrollment.
Are patients with RET alterations eligible?
No. RET mutation is an exclusion criterion.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages