OncoMatch/Clinical Trials/NCT06946797
A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC)
Is NCT06946797 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for non-small cell lung cancer.
Treatment: Nivolumab · Ipilimumab · Carboplatin · Paclitaxel · Pemetrexed · Cisplatin — The purpose of this study is to evaluate two dosing regimens of subcutaneous Nivolumab in combination with intravenous Ipilimumab and chemotherapy in participants with previously untreated metastatic or recurrent Non-Small Cell Lung Cancer (NSCLC)
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Excluded: EGFR mutation
Participants must not have any known driver mutations with available targeted therapy (including but not limited to EGFR mutations...)
Excluded: ALK translocation
Participants must not have any known driver mutations with available targeted therapy (including but not limited to...ALK translocations...)
Excluded: ROS1 translocation
Participants must not have any known driver mutations with available targeted therapy (including but not limited to...ROS-1 translocations...)
Excluded: BRAF V600E
Participants must not have any known driver mutations with available targeted therapy (including but not limited to...known BRAFV600E...)
Excluded: RET activating mutation
participants with a known activating RET mutations
Excluded: NTRK1 fusion gene alteration
participants with a known...NTRK fusion gene alterations
Excluded: NTRK2 fusion gene alteration
participants with a known...NTRK fusion gene alterations
Excluded: NTRK3 fusion gene alteration
participants with a known...NTRK fusion gene alterations
Disease stage
Required: Stage IV (IASLC 9th edition)
stage IV or recurrent non-small cell lung cancer (NSCLC) (as defined by the 9th edition of the IASLC Lung Cancer Staging Guidelines)
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: anti-PD-1 therapy
Participants must not have any prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways.
Cannot have received: anti-PD-L1 therapy
Participants must not have any prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways.
Cannot have received: anti-PD-L2 therapy
Participants must not have any prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways.
Cannot have received: anti-CTLA-4 therapy
Participants must not have any prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways.
Cannot have received: EGFR tyrosine kinase inhibitor
Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.
Cannot have received: ALK inhibitor
Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.
Cannot have received: ROS1 inhibitor
Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.
Cannot have received: BRAF inhibitor
Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.
Cannot have received: RET inhibitor
Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.
Cannot have received: NTRK inhibitor
Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Alaska Oncology and Hematology · Anchorage, Alaska
- USC/Norris Comprehensive Cancer Center · Los Angeles, California
- Local Institution - 0088 · Newport Beach, California
- Local Institution - 0063 · Boise, Idaho
- Saint Alphonsus Regional Medical Center · Boise, Idaho
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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