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OncoMatch/Clinical Trials/NCT06946797

A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC)

Is NCT06946797 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for non-small cell lung cancer.

Phase 2RecruitingBristol-Myers SquibbNCT06946797Data as of May 2026

Treatment: Nivolumab · Ipilimumab · Carboplatin · Paclitaxel · Pemetrexed · CisplatinThe purpose of this study is to evaluate two dosing regimens of subcutaneous Nivolumab in combination with intravenous Ipilimumab and chemotherapy in participants with previously untreated metastatic or recurrent Non-Small Cell Lung Cancer (NSCLC)

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Extracted eligibility criteria

Cancer type

Non-Small Cell Lung Carcinoma

Biomarker criteria

Excluded: EGFR mutation

Participants must not have any known driver mutations with available targeted therapy (including but not limited to EGFR mutations...)

Excluded: ALK translocation

Participants must not have any known driver mutations with available targeted therapy (including but not limited to...ALK translocations...)

Excluded: ROS1 translocation

Participants must not have any known driver mutations with available targeted therapy (including but not limited to...ROS-1 translocations...)

Excluded: BRAF V600E

Participants must not have any known driver mutations with available targeted therapy (including but not limited to...known BRAFV600E...)

Excluded: RET activating mutation

participants with a known activating RET mutations

Excluded: NTRK1 fusion gene alteration

participants with a known...NTRK fusion gene alterations

Excluded: NTRK2 fusion gene alteration

participants with a known...NTRK fusion gene alterations

Excluded: NTRK3 fusion gene alteration

participants with a known...NTRK fusion gene alterations

Disease stage

Required: Stage IV (IASLC 9th edition)

stage IV or recurrent non-small cell lung cancer (NSCLC) (as defined by the 9th edition of the IASLC Lung Cancer Staging Guidelines)

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: anti-PD-1 therapy

Participants must not have any prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways.

Cannot have received: anti-PD-L1 therapy

Participants must not have any prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways.

Cannot have received: anti-PD-L2 therapy

Participants must not have any prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways.

Cannot have received: anti-CTLA-4 therapy

Participants must not have any prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways.

Cannot have received: EGFR tyrosine kinase inhibitor

Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.

Cannot have received: ALK inhibitor

Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.

Cannot have received: ROS1 inhibitor

Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.

Cannot have received: BRAF inhibitor

Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.

Cannot have received: RET inhibitor

Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.

Cannot have received: NTRK inhibitor

Participants must have no prior systemic anti-cancer treatment (including EGFR, ALK, ROS-1, BRAF, RET, and NTRK inhibitors) given as primary therapy for advanced or metastatic disease.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Alaska Oncology and Hematology · Anchorage, Alaska
  • USC/Norris Comprehensive Cancer Center · Los Angeles, California
  • Local Institution - 0088 · Newport Beach, California
  • Local Institution - 0063 · Boise, Idaho
  • Saint Alphonsus Regional Medical Center · Boise, Idaho

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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