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OncoMatch/Clinical Trials/NCT06941857

NC410 and FOLFIRINOX in Combination With Nivolumab With or Without Ipilimumab in Patients With Untreated Metastatic Pancreatic Cancer

Is NCT06941857 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for pancreatic cancer.

Phase 2RecruitingSidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT06941857Data as of May 2026

Treatment: Oxaliplatin · Irinotecan · Folinic Acid · 5-Fluorouracil (5-FU) · NC410 · Nivolumab · IpilimumabThe purpose of this study is to evaluate safety of the treatment regimen and identify any novel toxicities.

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Extracted eligibility criteria

Cancer type

Pancreatic Cancer

Disease stage

Metastatic disease required

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: chemotherapy

Have had prior chemotherapy for pancreatic cancer or prior chemotherapy within 5 years of enrollment for other cancer diagnoses.

Cannot have received: radiation therapy

Has received radiotherapy for pancreatic cancer.

Cannot have received: anti-PD-1 therapy

Has received prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4, or anti-Lag-3 antibodies.

Cannot have received: investigational agent

Are receiving or have received any investigational agent or used an investigational device within 28 days prior to Day 1 of treatment in this study.

Lab requirements

Blood counts

adequate organ and marrow function defined by study-specified laboratory tests and procedures

Kidney function

adequate organ and marrow function defined by study-specified laboratory tests and procedures

Liver function

adequate organ and marrow function defined by study-specified laboratory tests and procedures

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Sidney Kimmel Comprehensive Cancer Center · Baltimore, Maryland

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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