OncoMatch/Clinical Trials/NCT06939127
Cryoablation Combined With Tislelizumab and Chemotherapy as Neoadjuvant and Adjuvant Therapy in Resectable Stage II-IIIB NSCLC
Is NCT06939127 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Neoadjuvant Cryoablation Combined with Tislelizumab and Chemotherapy and Adjuvant tislelizumab for nsclc (non-small cell lung cancer).
Treatment: Neoadjuvant Cryoablation Combined with Tislelizumab and Chemotherapy · Adjuvant tislelizumab — This is a Phase II single-arm study designed to evaluate the efficacy and safety of cryoablation combined with tislelizumab and platinum-based doublet chemotherapy as neoadjuvant therapy, followed by adjuvant tislelizumab therapy in patients with resectable stage II-IIIB non-small cell lung cancer (NSCLC). The study consists of a screening phase, a treatment phase (including the neoadjuvant stage, surgery, and adjuvant stage), a safety follow-up period, and a survival follow-up period.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Excluded: EGFR mutation
Known EGFR mutations [excluded]. For non-squamous NSCLC, EGFR mutation status must be confirmed locally or centrally if unknown.
Excluded: ALK fusion
Known...ALK translocations [excluded].
Disease stage
Required: Stage II, IIIA, IIIB (AJCC 9th edition)
Excluded: Stage IV, IIIC
Histologically confirmed stage II-IIIB NSCLC (AJCC 9th edition). Locally advanced, unresectable disease, regardless of stage or metastasis (stage IV) [excluded]. Patients with mediastinal lymph node involvement on CT must undergo sampling for clinical staging to exclude stage IIIB/C.
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: chemotherapy
Cannot have received: radiation therapy
Lab requirements
Cardiac function
adequate cardiopulmonary function for radical surgical resection
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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