OncoMatch/Clinical Trials/NCT06934382
Anti-CD7 CAR-T Cells in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia or Lymphoma
Is NCT06934382 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies Allogeneic anti-CD7 CAR-T cells (BEAM-201) for t-cell acute lymphoblastic leukemia/lymphoma.
Treatment: Allogeneic anti-CD7 CAR-T cells (BEAM-201) — This will be a Phase 1, open-label study to evaluate the safety and efficacy of BEAM-201 in patients with R/R T-ALL or T-LLy. BEAM-201 is an allogeneic anti-CD7 CART therapy.
Check if I qualifyExtracted eligibility criteria
Cancer type
Acute Lymphoblastic Leukemia
Non-Hodgkin Lymphoma
Biomarker criteria
Required: CD7 expression (at least 90% of blasts positive)
Prior therapy
Must have received: chemotherapy — induction and/or re-induction
second or greater relapse, first relapse post-transplant, or chemotherapy-refractory disease
Cannot have received: CD7 targeted therapy
Receipt of prior CD7 targeted therapy
Cannot have received: radiation therapy
Exception: prophylaxis for CNS disease
Radiation therapy within 2 weeks prior to completion of screening, other than prophylaxis for CNS disease
Lab requirements
Kidney function
Adequate Serum creatinine based on age/gender
Liver function
ALT ≤ 5x ULN in the absence of ALL infiltration of the liver; Bilirubin ≤ 3 × ULN for age (exceptions if abnormalities are directly related to ALL infiltration of the liver)
Cardiac function
ECHO with LVSF ≥ 30% or LVEF ≥ 50%; or qualitative normal ventricular function by cardiologist
Adequate organ function defined as: Adequate Serum creatinine based on age/gender; ALT ≤ 5x ULN in the absence of ALL infiltration of the liver; Bilirubin ≤ 3 × ULN for age... Cardiac echocardiography (ECHO) with left ventricular shortening fraction (LVSF) ≥ 30% or left ventricular ejection fraction (LVEF) ≥ 50%. In cases where quantitative assessment of LVSF/LVEF is not possible, a statement by the cardiologist that the ECHO shows qualitatively normal ventricular function will suffice
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Children's Hospital of Philadelphia · Philadelphia, Pennsylvania
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