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OncoMatch/Clinical Trials/NCT06934044

A Study Evaluating the Pharmacokinetics, Safety, and Efficacy of Cevostamab in Chinese Participants With Relapsed or Refractory Multiple Myeloma

Is NCT06934044 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies multiple treatments including Cevostamab and Tocilizumab for multiple myeloma.

Phase 1RecruitingHoffmann-La RocheNCT06934044Data as of Jun 2026Location: China

Treatment: Cevostamab · TocilizumabThis study will evaluate the pharmacokinetics (PK), safety, and efficacy of cevostamab in participants with relapsed or refractory (R/R) multiple myeloma (MM).

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Extracted eligibility criteria

Treatments studied

Other

CevostamabTocilizumab

Cancer type

Multiple Myeloma

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Cannot have received: cevostamab or another agent with the same target

Prior treatment with cevostamab or another agent with the same target

Cannot have received: monoclonal antibody

Exception: except for the use of non-myeloma therapy

Prior use of any monoclonal antibody (mAb), radioimmunoconjugate, or ADC as anti-cancer therapy within 4 weeks before first study treatment, except for the use of non-myeloma therapy

Cannot have received: systemic immunotherapeutic agents

Prior treatment with systemic immunotherapeutic agents, including but not limited to, cytokine therapy and anti-CTLA-4, anti-PD-1, and anti-PD-L1

Cannot have received: CAR-T cell therapy

Prior treatment with CAR-T cell therapy within 12 weeks before first cevostamab infusion

Cannot have received: radiotherapy

Treatment with radiotherapy, any chemotherapeutic agent, or treatment with any other anti-cancer agent within 4 weeks or 5 half-lives of the drug, whichever is shorter, prior to first study treatment

Cannot have received: chemotherapeutic agent

Treatment with radiotherapy, any chemotherapeutic agent, or treatment with any other anti-cancer agent within 4 weeks or 5 half-lives of the drug, whichever is shorter, prior to first study treatment

Cannot have received: anti-cancer agent

Treatment with radiotherapy, any chemotherapeutic agent, or treatment with any other anti-cancer agent within 4 weeks or 5 half-lives of the drug, whichever is shorter, prior to first study treatment

Cannot have received: autologous stem cell transplantation

Autologous stem cell transplantation (SCT) within 100 days prior to first study treatment

Cannot have received: allogeneic stem cell transplantation

Prior allogeneic SCT

Cannot have received: solid organ transplantation

Prior solid organ transplantation

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Frequently asked questions

Is NCT06934044 currently recruiting?

Yes, this trial is currently recruiting patients.

Are there prior therapy exclusions?

Yes. Prior cevostamab or another agent with the same target, monoclonal antibody, systemic immunotherapeutic agents disqualifies patients from enrollment.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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