OncoMatch/Clinical Trials/NCT06933394
Arsenic Trioxide With MAPK Inhibitors and Chemotherapy for Stage 4/M Neuroblastoma
Is NCT06933394 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Arsenic trioxide and MAPK inhibitors for neuroblastoma.
Treatment: Arsenic trioxide · MAPK inhibitors · Chemotherapy — This prospective, single-arm, multi-center clinical trial aims to explore and evaluate the efficacy and safety of the combination therapy involving arsenic trioxide, MAPK inhibitors, and chemotherapy for stage 4/M neuroblastoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Neuroblastoma
Disease stage
Required: Stage INRG M, INSS STAGE 4
Metastatic disease required
Preoperative staging as INRG M stage or postoperative staging as INSS stage 4 (regardless of risk classification).
Prior therapy
Cannot have received: chemotherapy and abdominal radiation therapy
Lab requirements
Kidney function
glomerular filtration rate (GFR) < 30 ml/(min·1.73 m²) or serum creatinine > 5 mg/dL (442 μmol/L) [excluded]
Liver function
aspartate aminotransferase (AST), alanine aminotransferase (ALT) ≥ 5× upper limit of normal (ULN), or serum total bilirubin ≥ 3× ULN [excluded]
Cardiac function
NYHA heart function class III or IV, or left ventricular ejection fraction (LVEF) < 50% [excluded]
Severe progressive or persistent heart failure: NYHA heart function class III or IV, or left ventricular ejection fraction (LVEF) < 50%. Severe progressive or persistent renal failure: glomerular filtration rate (GFR) < 30 ml/(min·1.73 m²) or serum creatinine > 5 mg/dL (442 μmol/L). Severe liver dysfunction: aspartate aminotransferase (AST), alanine aminotransferase (ALT) ≥ 5× upper limit of normal (ULN), or serum total bilirubin ≥ 3× ULN.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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