OncoMatch/Clinical Trials/NCT06925724
A Study of Ivonescimab in People With Endometrial and Cervical Cancers
Is NCT06925724 recruiting? Yes, currently enrolling (Sep 2026). This Phase 2 trial studies Ivonescimab for endometrial cancer.
Treatment: Ivonescimab — The researchers are doing this study to find out if ivonescimab is an effective treatment for people with endometrial cancer (EC) and/or cervical cancer (CC). The researchers will also look at whether the study drug is safe and causes few or mild side effects in participants.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Cancer type
Endometrial Cancer
Cervical Cancer
Disease stage
Metastatic disease required
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Demographics
Prior therapy
Must have received: platinum-based chemotherapy
has progressed after treatment with at least one platinum-based regimen
Lab requirements
Blood counts
Absolute neutrophil count (ANC) ≥1500/mm3 (≥1.5 × 10^3/µL); Platelets ≥100,000/µL; Hemoglobin ≥9.0 g/dL; International Normalized Ratio (INR) ≤1.5
Kidney function
Creatinine clearance (CrCl) ≥ 30 mL/min using the Cockcroft-Gault formula; Urine protein < 2+ (or 24 hour urine protein quantification < 1.0 g)
Liver function
Total bilirubin ≤1.5 ×ULN (patients with known Gilbert's disease who have bilirubin level ≤ 3 x ULN may be enrolled); AST and ALT ≤2.5 × ULN (≤5 × ULN for participants with liver metastases); TSH within normal limits. If TSH is not within normal range despite no symptoms of thyroid dysfunction, normal free T4 level is required.
Have adequate laboratory values as defined in the following table: Hematologic, Renal, Hepatic
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Memorial Sloan Kettering Basking Ridge (All Protocol Activities) · Basking Ridge, New Jersey
- Memorial Sloan Kettering Monmouth (All Protocol Activities) · Middletown, New Jersey
- Memorial Sloan Kettering Bergen (All Protocol Activities) · Montvale, New Jersey
- Memorial Sloan Kettering Suffolk- Commack (All Protocol Activities) · Commack, New York
- Memorial Sloan Kettering Westchester (All Protocol Activities) · Harrison, New York
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT06925724 currently recruiting?
Yes, this trial is currently recruiting patients.
Is prior treatment required for enrollment?
Yes. Patients must have previously received platinum-based chemotherapy.
Is this trial open to male patients?
No. This trial enrolls female patients only.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify