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OncoMatch/Clinical Trials/NCT06925724

A Study of Ivonescimab in People With Endometrial and Cervical Cancers

Is NCT06925724 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Ivonescimab for endometrial cancer.

Phase 2RecruitingMemorial Sloan Kettering Cancer CenterNCT06925724Data as of May 2026

Treatment: Ivonescimab — The researchers are doing this study to find out if ivonescimab is an effective treatment for people with endometrial cancer (EC) and/or cervical cancer (CC). The researchers will also look at whether the study drug is safe and causes few or mild side effects in participants.

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Extracted eligibility criteria

Cancer type

Endometrial Cancer

Cervical Cancer

Disease stage

Required: Stage IV

Metastatic disease required

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Min 1 prior line

Must have received: platinum-based chemotherapy

Lab requirements

Blood counts

ANC ≥1500/mm3; Platelets ≥100,000/µL; Hemoglobin ≥9.0 g/dL; INR ≤1.5; PT or INR ≤ 1.5 x ULN; PTT or aPTT ≤ 1.5 × ULN (unless abnormalities are unrelated to coagulopathy or prophylactic coagulation)

Kidney function

Creatinine clearance (CrCl) ≥ 50 mL/min; Urine protein < 2+ or 24 hour urine protein quantification < 1.0 g

Liver function

Total bilirubin ≤1.5 ×ULN (≤3 × ULN for Gilbert's disease); AST and ALT ≤2.5 × ULN (≤5 × ULN for liver metastases); TSH within normal limits or normal free T4 if TSH abnormal

Have adequate laboratory values as defined in the following table: ... see criteria for details

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Memorial Sloan Kettering Basking Ridge (All Protocol Activities) · Basking Ridge, New Jersey
  • Memorial Sloan Kettering Monmouth (All Protocol Activities) · Middletown, New Jersey
  • Memorial Sloan Kettering Bergen (All Protocol Activities) · Montvale, New Jersey
  • Memorial Sloan Kettering Suffolk- Commack (All Protocol Activities) · Commack, New York
  • Memorial Sloan Kettering Westchester (All Protocol Activities) · Harrison, New York

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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