OncoMatch/Clinical Trials/NCT06921837
A First-in-Human Study Using BDC-4182 as a Single Agent in Advanced Gastric and Gastroesophageal Cancer
Is NCT06921837 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1/2 trial studies BDC-4182 for gastric cancer adenocarcinoma metastatic.
Treatment: BDC-4182 — A first-in-human study using BDC-4182 as a single agent in gastric and gastroesophageal cancers
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Gastric Cancer
Esophageal Carcinoma
Biomarker criteria
Required: CLDN18 expression ≥ 1% of tumor cells IHC ≥ 2+ or Positive (≥ 1% of tumor cells IHC ≥ 2+ or Positive)
If prior Claudin 18 IHC expression is known, the subject must have some degree of Claudin 18 expression as defined as Positive or have expression ≥ 1% of tumor cells IHC ≥ 2+
Disease stage
Required: Stage STAGE 4, STAGE 3
metastatic (Stage 4) or unresectable (Stage 3)
Prior therapy
Must have received: locally available standard therapies
must have received at least 1-2 prior lines of locally available standard therapies or must be intolerant of standard therapies
Cannot have received: any investigational agent or standard anti-cancer therapies
Any investigational agent or standard anti-cancer therapies within 28 days before starting study treatment or within 5 estimated elimination half-lives, whichever is shorter
Lab requirements
Blood counts
Kidney function
Liver function
Cardiac function
Adequate organ function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06921837 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior any investigational agent or standard anti-cancer therapies disqualifies patients from enrollment.
Does this trial require CLDN18?
Yes, CLDN18 expression ≥ 1% of tumor cells IHC ≥ 2+ or Positive is a required biomarker for enrollment.
What disease stage is eligible?
Stage STAGE 4 or STAGE 3 is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages