OncoMatch/Clinical Trials/NCT06891157
Chidamide Plus R-CHOP in Newly Diagnosed Double-Expressor Diffuse Large B-Cell Lymphoma With Other Molecular Subtypes
Is NCT06891157 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Chidamide plus R-CHOP for chidamide.
Treatment: Chidamide plus R-CHOP — Evaluation of the Safety and Efficacy of CR-CHOP Treatment in Newly Diagnosed Double-Expressor DLBCL with Other Molecular Subtypes
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Diffuse Large B-Cell Lymphoma
Non-Hodgkin Lymphoma
Biomarker criteria
Required: BCL2 overexpression (≥ 50%)
Required: MYC overexpression (≥ 40%)
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: lymphoma treatment
Lab requirements
Kidney function
serum creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 35 mL/min as calculated by the Cockcroft-Gault formula
Liver function
total bilirubin (TBIL) ≤ 3 × ULN; ALT and AST ≤ 5 × ULN; ALP ≤ 5 × ULN
Adequate hepatic function is defined as: total bilirubin (TBIL) ≤ 3 times the upper limit of normal (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤5 × ULN; alkaline phosphatase (ALP) ≤ 5 × ULN; serum creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 35 mL/min as calculated by the Cockcroft-Gault formula
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06891157 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
Does this trial require BCL2?
Yes, BCL2 overexpression is a required biomarker for enrollment.
Does this trial require MYC?
Yes, MYC overexpression is a required biomarker for enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify