OncoMatch/Clinical Trials/NCT06888843

Study to Evaluate the Use of Capecitabine in Monotherapy and in Combination With Oxaliplatin in Elderly Patients as Adjuvant Chemotherapy for Locally Advanced Colorectal Cancer.

Is NCT06888843 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Capecitabine and Oxaliplatin for colorectal cancer.

Phase 2RecruitingNizhny Novgorod Regional Clinical Oncology CenterNCT06888843Data as of May 2026

Treatment: Capecitabine · Oxaliplatin — All patients with locally advanced colorectal cancer after radical surgical intervention who have not previously received systemic antitumor treatment will be randomized into two groups receiving fluoropyrimidines in mono-regimen and in combination with oxaliplatin. Main objectives: * to compare the 3-year disease-free survival and 5-year overall survival rates in the two groups. * to identify, through a comprehensive geriatric assessment among elderly patients, the groups that benefit most from adjuvant chemotherapy. Patients will be treated until progression of the process is detected or the maximum effect of therapy is reached (the longest duration of treatment is 6 months).

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Extracted eligibility criteria

Cancer type

Colorectal Cancer

Biomarker criteria

Excluded: DPYD dihydropyrimidine dehydrogenase deficiency

Confirmed dihydropyrimidine dehydrogenase deficiency in blood by PCR (alteration of alleles c.[190511G > A], c.[1679T >G],[2846A > T], [1129-5923C >G], [c.1236 G>A(HapB3)])

Disease stage

Required: Stage III

Excluded: Stage I, II, IV

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)

Max 0 prior lines

Must have received: surgery — primary colorectal tumor

Underwent radical surgical intervention for primary colorectal tumor

Cannot have received: systemic therapy

Having previously received any systemic therapy for CRC

Lab requirements

Blood counts

Adequate bone marrow function

Kidney function

Adequate kidney function

Liver function

Adequate liver function

Adequate liver, kidney and bone marrow function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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