OncoMatch/Clinical Trials/NCT06878248
A Study to Assess CLBR001+ABBV-461 in Subjects With Locally Advanced or Metastatic Breast Cancer
Is NCT06878248 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies Two Component Product CLBR001 + ABBV-461 for breast cancer metastatic.
Treatment: Two Component Product CLBR001 + ABBV-461 — The goal of this clinical trial is to evaluate CLBR001 and ABBV-461 as a treatment for patients with locally advanced or metastatic breast cancer. The goals are to establish the safety and efficacy of the combination therapy while establishing the optimal biologic doses. Patients will be administered a single infusion of CLBR001 cells followed by cycles of ABBV-461 with regular assessments of safety and disease response to treatment.
Check if I qualifyExtracted eligibility criteria
Cancer type
Breast Carcinoma
Tumor Agnostic
Triple-Negative Breast Cancer
Disease stage
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: standard of care therapy
Exhaused all standard of care therapy options
Cannot have received: allogeneic stem cell transplant
Prior allogeneic stem cell transplant
Cannot have received: lentiviral- or retroviral-based therapy including CAR-T cell therapy
Prior lentiviral- or retroviral-based therapy including CAR-T cell therapy
Cannot have received: lymphodepleting or T-cell cytotoxic therapy
Prior lymphodepleting or T-cell cytotoxic therapy within 3 months of enrollment
Lab requirements
Blood counts
Kidney function
Liver function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Augusta University Medical Center · Augusta, Georgia
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center · Indianapolis, Indiana
- Roswell Park Cancer Institute · Buffalo, New York
- University of Virginia · Charlottesville, Virginia
- Fred Hutchinson Cancer Center · Seattle, Washington
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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