OncoMatch/Clinical Trials/NCT06855524
Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal or Gynecological Cancer
Is NCT06855524 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for malignant digestive system neoplasm.
This clinical trial tests how well fucoidan works in preventing chemotherapy-related fatigue compared to a placebo in patients with gastrointestinal (GI) or gynecological (GYN) cancer. Fatigue poses a burden in patients with malignancies undergoing systemic chemotherapy. Fucoidan is a dietary supplement made of complex sugar that contain sulfate groups attached to their sugar units (sulfated polysaccharide) which found in brown seaweed. It is thought to have anti-inflammatory, anti-viral, anti-thrombotic, anti-diabetic, and anti-tumor effects in pre-clinical models. Giving fucoidan may be effective in preventing chemotherapy-related fatigue in patients with GI or GYN.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Gastric Cancer
Hepatocellular Carcinoma
Pancreatic Cancer
Cholangiocarcinoma
Esophageal Carcinoma
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: chemotherapy and/or immunotherapy
Use of chemotherapy and/or immunotherapy ≤ 90 days prior to registration
Lab requirements
Blood counts
Hemoglobin ≥ 10 g/dL (obtained ≤ 30 days prior to registration)
Kidney function
Creatinine ≤ 1.5 x upper normal limit (UNL) OR calculated creatinine clearance ≥ 50 ml/min using the Cockcroft-Gault (obtained ≤ 30 days prior to registration)
Liver function
ALT and AST ≤ 1.5 x UNL; ≤ 5 x ULN for patients with liver involvement (obtained ≤ 30 days prior to registration)
Hemoglobin ≥ 10 g/dL (obtained ≤ 30 days prior to registration); Creatinine ≤ 1.5 x upper normal limit (UNL) OR calculated creatinine clearance ≥ 50 ml/min using the Cockcroft-Gault (obtained ≤ 30 days prior to registration); ALT and AST ≤ 1.5 x UNL; ≤ 5 x ULN for patients with liver involvement (obtained ≤ 30 days prior to registration)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Mayo Clinic in Arizona · Scottsdale, Arizona
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