OncoMatch/Clinical Trials/NCT06846671
A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
Is NCT06846671 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments for cll.
Treatment: BGB-16673 · Bendamustine · Idelalisib · Rituximab · Venetoclax — The purpose of this study is to investigate the efficacy and safety of BGB-16673 compared with investigator's choice (idelalisib plus rituximab \[for CLL only\] or bendamustine plus rituximab or venetoclax plus rituximab retreatment) in participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) previously exposed to both BTK inhibitors (BTKi) and BCL2 inhibitors (BCL2i).
Check if I qualifyExtracted eligibility criteria
Cancer type
Chronic Lymphocytic Leukemia
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: BTK inhibitor
Previously received treatment for CLL/SLL with both a BTKi and a BCL2i
Must have received: BCL2 inhibitor
Previously received treatment for CLL/SLL with both a BTKi and a BCL2i
Cannot have received: autologous stem cell transplant
Exception: within last 3 months
Prior autologous stem cell transplant or chimeric antigen receptor-T cell therapy in the last 3 months
Cannot have received: CAR-T cell therapy
Exception: within last 3 months
Prior autologous stem cell transplant or chimeric antigen receptor-T cell therapy in the last 3 months
Cannot have received: BTK protein degrader
Prior exposure to any BTK protein degraders
Lab requirements
Liver function
Adequate liver function
Adequate liver function; Adequate blood clotting function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- St Bernards Medical Center · Jonesboro, Arkansas
- UCLA Department of Medicine Hematologyoncology · Los Angeles, California
- Pih Health Whittier Hospital · Whittier, California
- Rocky Mountain Cancer Centers (Williams) Usor · Aurora, Colorado
- Florida Oncology and Hematology · Fort Myers, Florida
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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