OncoMatch/Clinical Trials/NCT06823427
9MW2821 + Toripalimab vs 9MW2821 for 1st Line Locally Advanced or Metastatic Urothelial Carcinoma
Is NCT06823427 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including 9MW2821 and Toripalimab (JS001 ) for urothelial carcinoma.
Treatment: 9MW2821 · Toripalimab (JS001 ) — This study will compare the efficacy of 9MW2821+toripalimab versus 9MW2821 monotherapy in locally advanced or metastatic urothelial carcinoma patients who have not received any systemic treatment in the metastatic or advanced setting.
Check if I qualifyExtracted eligibility criteria
Cancer type
Urothelial Carcinoma
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: anti-PD-1 therapy
Have received prior treatment with anti-PD-1, anti-PD-L1/PD-L2 or anti-CTLA-4 therapies
Cannot have received: anti-PD-L1 therapy
Have received prior treatment with anti-PD-1, anti-PD-L1/PD-L2 or anti-CTLA-4 therapies
Cannot have received: anti-PD-L2 therapy
Have received prior treatment with anti-PD-1, anti-PD-L1/PD-L2 or anti-CTLA-4 therapies
Cannot have received: anti-CTLA-4 therapy
Have received prior treatment with anti-PD-1, anti-PD-L1/PD-L2 or anti-CTLA-4 therapies
Cannot have received: Nectin-4 targeted therapy
Have received prior treatment with Nectin-4 targeted therapy or ADC with MMAE as payload
Cannot have received: antibody-drug conjugate
Exception: ADC with MMAE as payload
Have received prior treatment with Nectin-4 targeted therapy or ADC with MMAE as payload
Cannot have received: allogeneic hematological stem cell transplantation
Have received allogeneic hematological stem cell transplantation or solid organ transplant
Cannot have received: solid organ transplant
Have received allogeneic hematological stem cell transplantation or solid organ transplant
Lab requirements
Blood counts
Appropriate hematological functions
Kidney function
Appropriate organ functions
Liver function
Appropriate organ functions
Appropriate hematological and organ functions
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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