OncoMatch/Clinical Trials/NCT06811233
Monitoring, Detoxifying, and Rebalancing Metals During Acute Myeloid Leukemia (AML) Therapy, a Phase 2 Randomized Study
Is NCT06811233 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies multiple treatments including DMSA and Ca-EDTA for acute myeloid leukemia (aml).
Treatment: DMSA · Ca-EDTA · Magnesium Sulfate · Multivitamin — The goal of this clinical research study is to learn if metal detoxification (with calcium disodium edetate \[Ca-EDTA\] and dimercaptosuccinic acid \[DMSA\]) during standard therapy can help improve outcomes in patients with intermediate-risk, high-risk, or secondary AML compared to standard therapy alone. Researchers think lowering the level of metals found in the blood/bone marrow may help to control the disease and/or improve the response to chemotherapy.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Acute Myeloid Leukemia
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: bcl2 inhibitor (venetoclax)
Lab requirements
Kidney function
Serum creatinine ≤ 2.0 mg/dL
Liver function
Total Bilirubin ≤ 2.0 x ULN unless the patient has Gilbert's; AST (SGOT) and/or ALT (SGPT) ≤ 2.0 x ULN
Laboratory test results within these ranges (unless due to leukemia or other hematologic malignancy): Serum creatinine ≤ 2.0 mg/dL; Total Bilirubin ≤ 2.0 x ULN unless the patient has Gilbert's; AST (SGOT) and/or ALT (SGPT) ≤ 2.0 x ULN
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- The University of Texas M. D. Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT06811233 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior bcl2 inhibitor disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages