OncoMatch

OncoMatch/Clinical Trials/NCT06792695

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

Is NCT06792695 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Volrustomig and FOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan) for metastatic colorectal cancer.

Phase 2RecruitingAstraZenecaNCT06792695Data as of May 2026

Treatment: Volrustomig · FOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan) · BevacizumabThe main purpose of this study is to evaluate the safety and efficacy of novel study interventions and combinations in participants with Colorectal Cancer (CRC).

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Extracted eligibility criteria

Cancer type

Colorectal Cancer

Biomarker criteria

Required: MMR proficient

Known pMMR/MSS status (only pMMR/MSS mCRC allowed).

Required: MSH2 microsatellite stable

Known pMMR/MSS status (only pMMR/MSS mCRC allowed).

Disease stage

Metastatic disease required

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: immune mediated therapy

Lab requirements

Blood counts

Adequate organ and bone marrow function

Kidney function

Adequate organ and bone marrow function

Liver function

Adequate organ and bone marrow function

Adequate organ and bone marrow function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Research Site · Scottsdale, Arizona
  • Research Site · Los Angeles, California
  • Research Site · Washington D.C., District of Columbia
  • Research Site · Chicago, Illinois
  • Research Site · Baltimore, Maryland

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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