OncoMatch/Clinical Trials/NCT06788912
Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)
Is NCT06788912 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for lung neoplasm malignant.
Treatment: Pembrolizumab (neoadjuvant) · Cisplatin · Gemcitabine · Pemetrexed · Sacituzumab tirumotecan · H1 receptor antagonist · H2 receptor antagonist · Acetaminophen (or equivalent) · Dexamethasone (or equivalent) · Carboplatin · Pembrolizumab (adjuvant) · Paclitaxel · Steroid mouthwash (dexamethasone or equivalent) — The main goals are after treatment given before surgery, to measure the number of people who have no signs of cancer cells in tumors and lymph nodes removed during surgery; and to learn about whether the cancer gets smaller or goes away by measuring the number of people with a certain number of living cancer cells in the tumor removed during surgery.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Required: EGFR wild-type
Disease stage
Required: Stage II, IIIA, IIIB (N2)
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: radiation therapy
Exception: prior radiotherapy within 2 weeks of start of study intervention, or radiation related toxicities, requiring corticosteroids
Received prior radiotherapy within 2 weeks of start of study intervention, or radiation related toxicities, requiring corticosteroids
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Southern Cancer Center (SCC) ( Site 8004) · Daphne, Alabama
- Sansum Clinic (Ridley Tree) ( Site 8012) · Santa Barbara, California
- Rocky Mountain Cancer Centers (RMCC) ( Site 8011) · Lone Tree, Colorado
- MedStar Franklin Square Medical Center ( Site 0033) · Baltimore, Maryland
- Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8006) · Eugene, Oregon
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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