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OncoMatch/Clinical Trials/NCT06783140

Study of NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Pancreatic Cancer

Is NCT06783140 recruiting? Yes, currently enrolling (May 2026). This Phase 2/3 trial studies multiple treatments including Nab paclitaxel and Gemcitabine for pancreatic cancer, advanced or metastatic.

Phase 2/3RecruitingUniversity Health Network, TorontoNCT06783140Data as of May 2026

Treatment: Nab paclitaxel · Gemcitabine · CisplatinThis study will compare two different regimens for patients with BRCA1/2 or PALB2 mutated metastatic pancreatic cancer after progression on first-line FOLFIRINOX.

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Extracted eligibility criteria

Cancer type

Pancreatic Cancer

Biomarker criteria

Required: BRCA1 mutation (somatic or germline)

BRCA1/2 or PALB2 mutation (somatic or germline)

Required: BRCA2 mutation (somatic or germline)

BRCA1/2 or PALB2 mutation (somatic or germline)

Required: PALB2 mutation (somatic or germline)

BRCA1/2 or PALB2 mutation (somatic or germline)

Disease stage

Metastatic disease required

Metastatic pancreatic adenocarcinoma

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Min 1 prior line

Must have received: FOLFIRINOX or NALIRIFOX (FOLFIRINOX, NALIRIFOX) — first-line for metastatic disease

Clinical or radiographic progression on first-line FOLFIRINOX (or NALIRIFOX) for metastatic disease.

Cannot have received: cisplatin (cisplatin)

Patients may not have received prior cisplatin for their pancreatic cancer in any setting.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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