OncoMatch/Clinical Trials/NCT06769490
Dose Escalation and Expansion of Ziftomenib in Combination With Quizartinib in Acute Myeloid Leukemia
Is NCT06769490 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including Ziftomenib and Quizartinib for acute myeloid leukemia.
Treatment: Ziftomenib · Quizartinib — The goal of this all-oral combination is to deliver safe and effective therapy for the largest portion of AML subtypes (NPM1mt, KMT2Ar, NUP98r \~ 40-45%).
Check if I qualifyExtracted eligibility criteria
Cancer type
Acute Myeloid Leukemia
Biomarker criteria
Required: KMT2A (MLL) rearrangement
Required: NPM1 mutation
Required: NUP98 rearrangement
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: menin inhibitor
Prior treatment with a menin inhibitor
Lab requirements
Kidney function
estimated glomerular filtration rate > 50 mL/min (using Cockcroft-Gault) unless related to disease
Liver function
total bilirubin < 2x ULN unless increase is due leukemic involvement (<2.5 ULN), unless due to ongoing hemolysis or Gilbert's syndrome and AST and/or ALT < 3x ULN unless considered due to leukemic involvement, in which case direct bilirubin or AST and/or ALT < 5x ULN will be considered eligible
Cardiac function
Baseline ejection fraction must be > 40%
Adequate hepatic function (total bilirubin < 2x upper limit of normal (ULN) unless increase is due leukemic involvement (<2.5 ULN), unless due to ongoing hemolysis or Gilbert's syndrome and AST and/or ALT < 3x ULN unless considered due to leukemic involvement, in which case direct bilirubin or AST and/or ALT < 5x ULN will be considered eligible). Adequate renal function with an estimated glomerular filtration rate > 50 mL/min (using Cockcroft-Gault) unless related to disease. Baseline ejection fraction must be > 40%.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- The University of Texas M. D. Anderson Cancer Center · Houston, Texas
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