OncoMatch/Clinical Trials/NCT06768931
Biolosion Combined Standard Neoadjuvant Therapy to Treat Triple-negative Breast Cancer
Is NCT06768931 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for breast cancer.
To evaluate the efficacy and safety of compound preparation Biolosion in combination with standard neoadjuvant therapy for locally advanced triple-negative breast cancer
Check if I qualifyExtracted eligibility criteria
Cancer type
Breast Carcinoma
Triple-Negative Breast Cancer
Biomarker criteria
Required: ESR1 ≤10% expression (≤10%)
ER≤10%
Required: PR (PGR) ≤10% expression (≤10%)
PR≤10%
Required: HER2 (ERBB2) negative (negative)
HER-2 negative
Required: PD-L1 (CD274) expression testing required
tumor specimens ... available for PD-L1 expression testing
Disease stage
Required: Stage IIA, IIB, IIIA, IIIB, IIIC
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: chemotherapy
Exception: for advanced breast cancer
Patients must not have received chemotherapy or targeted therapy for advanced breast cancer
Cannot have received: targeted therapy
Exception: for advanced breast cancer
Patients must not have received chemotherapy or targeted therapy for advanced breast cancer
Cannot have received: immune checkpoint inhibitor
Previous treatment with immune checkpoint inhibitors
Lab requirements
Blood counts
anc≥1.5×10^9/l, plt≥75×10^9/l, hb≥90g/l (no blood transfusions or blood products within 14 days, and no use of g-csf or other hematopoietic growth factors for correction)
Kidney function
bun and cr≤1×uln or endogenous creatinine clearance ≥50ml/min (cockcroft-gault formula)
Liver function
tbil<1.5×uln, alt, ast<2.5×uln, for patients with liver metastasis, alt, ast may be <5×uln
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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