OncoMatch/Clinical Trials/NCT06768489
A Study of JNJ-79635322 in Combination With Daratumumab With or Without Lenalidomide or in Combination With Pomalidomide for Multiple Myeloma
Is NCT06768489 recruiting? Yes, currently enrolling (Sep 2026). This Phase 1 trial studies multiple treatments including JNJ-79635322 and Daratumumab for multiple myeloma.
Treatment: JNJ-79635322 · Daratumumab · Pomalidomide · Lenalidomide — The primary purpose of this study for Part 1 (Dose Escalation) is to identify the safe effective dose (recommended Phase 2 doses \[RP2Ds\]) and schedule for JNJ-79635322 treatment regimen in combination with daratumumab with or without lenalidomide or with pomalidomide; and for Part 2 (Dose Expansion) is to further characterize the safety and tolerability of JNJ-79635322 combination treatment regimens at selected RP2D(s).
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Endocrine / hormonal
Other
Cancer type
Multiple Myeloma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: proteasome inhibitor — multiple myeloma
Must have received: immunomodulatory drug — multiple myeloma
Must have received: proteasome inhibitor — multiple myeloma
Must have received: lenalidomide (lenalidomide) — multiple myeloma
Cannot have received: cd3-redirecting therapy
Lab requirements
Cardiac function
cardiac conditions (myocardial infarction, unstable angina, or coronary artery bypass graft <=6 months prior to enrollment; new york heart association stage iii or iv congestive heart failure et cetera)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06768489 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior cd3-redirecting therapy disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages