OncoMatch/Clinical Trials/NCT06763341
A Phase 1 Study of AOH1996 in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Is NCT06763341 recruiting? Yes, currently enrolling (Oct 2026). This Phase 1 trial studies multiple treatments including Azacitidine and PCNA Inhibitor AOH1996 for recurrent acute myeloid leukemia.
Treatment: Azacitidine · PCNA Inhibitor AOH1996 · Venetoclax — This phase 1 trial tests safety, side effects, and best dose of AOH1996 for the treatment of patients with acute myeloid leukemia (AML) that has come back after a period of improvement (relapsed) or AML that has not responded to previous treatment (refractory). AOH1996 is in a class of medications called PCNA inhibitors. It inhibits cancer growth and induces deoxyribonucleic acid (DNA) damage. This may help keep cancer cells from growing and damage cancer cell DNA. Giving AOH1996 may be safe, tolerable and/or effective in treating patients with AML.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Targeted therapy
Chemotherapy
Other
Cancer type
Acute Myeloid Leukemia
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Lab requirements
Blood counts
White blood cell (WBC) ≤ 25 x 10^9/L prior to initiation of study therapy
Kidney function
Creatinine clearance of ≥ 50 mL/min per 24 hour urine test or the Cockcroft-Gault formula
Liver function
Total bilirubin ≤ 1.5 X upper limit of normal (ULN); AST ≤ 3.0 x ULN; ALT ≤ 3.0 x ULN
Cardiac function
Corrected QT interval (QTc)F ≤ 480 ms based on Fridericia's formula
WBC ≤ 25 x 10^9/L; Total bilirubin ≤ 1.5 X ULN; AST ≤ 3.0 x ULN; ALT ≤ 3.0 x ULN; Creatinine clearance of ≥ 50 mL/min; INR or PT ≤ 1.5 x ULN; aPTT ≤ 1.5 x ULN; QTcF ≤ 480 ms
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- City of Hope Medical Center · Duarte, California
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT06763341 currently recruiting?
Yes, this trial is currently recruiting patients.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages