OncoMatch

OncoMatch/Clinical Trials/NCT06755684

Neoadjuvant Befotertinib Combined Bevacizumab or Platinum-based Double Chemotherapy for Resectable Locally-advanced EGFR Mutation-positive Non-Small Cell Lung Cancer

Is NCT06755684 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Befotertinib combined Bevacizumab and Befotertinib combined platinum-based double chemotherapy for egfr.

Phase 2RecruitingPeng ZhangNCT06755684Data as of May 2026

Treatment: Befotertinib combined Bevacizumab · Befotertinib combined platinum-based double chemotherapyThis study targeted patients with resectable stage II-IIIA non-small cell lung cancer with EGFR mutation

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Extracted eligibility criteria

Cancer type

Non-Small Cell Lung Carcinoma

Biomarker criteria

Required: EGFR sensitive mutation

Disease stage

Required: Stage II, IIIA

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: systemic anti-cancer treatment

The patient has undergone any systemic anti-cancer treatment for NSCLC, including surgical treatment, local radiotherapy, cytotoxic drug treatment, targeted drug treatment and experimental treatment, etc.

Lab requirements

Blood counts

Other major organs shall function well (liver, kidney, blood system, etc.)

Kidney function

Other major organs shall function well (liver, kidney, blood system, etc.)

Liver function

Other major organs shall function well (liver, kidney, blood system, etc.)

Other major organs shall function well (liver, kidney, blood system, etc.)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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