OncoMatch/Clinical Trials/NCT06745999
Cryotherapy in Combination with Red Light PDT for Actinic Keratosis of Full Face
Is NCT06745999 recruiting? Yes, currently enrolling (May 2026). This Phase 4 trial studies multiple treatments including Ameluz 10% Topical Gel and Red Light PDT for actinic keratoses.
Treatment: Ameluz 10% Topical Gel · Red Light PDT — 40 patients randomized 1:1 to receive cryotherapy followed by 10% ALA gel Red light PDT vs. to 10% ALA gel Red Light PDT followed by cryotherapy.
Check if I qualifyExtracted eligibility criteria
Disease stage
Grade: IIIIII
6-12 actinic keratosis grade I, II, and III on the full face.
Prior therapy
Cannot have received: topical therapy for actinic keratosis (5-fluorouracil, imiquimod, ingenol mebutate, diclofenac, photodynamic therapy)
Treatment with 5-fluorouracil (5-FU), imiquimod, ingenol mebutate, diclofenac, photodynamic therapy, or other topicals and treatments for AK within the treatment area or within 2 cm of the treatment area, within 12 weeks of baseline.
Cannot have received: local destructive therapy (liquid nitrogen, excision, curettage, dermabrasion, chemical peel, laser resurfacing)
Use of liquid nitrogen, excision, curettage, dermabrasion, chemical peel or laser resurfacing in the treatment area within 60 days.
Cannot have received: systemic retinoid (isotretinoin, acitretin)
Use of systemic retinoids (eg, isotretinoin, acitretin) within 6 months
Cannot have received: investigational drug
Use of any investigational drug within 4 weeks prior to enrollment or within 5 pharmacokinetic/pharmacodynamic half-lives, if known (whichever is longer).
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Psoriasis Treatment Center of New Jersey · East Windsor, New Jersey
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify