OncoMatch/Clinical Trials/NCT06732492
RD13-02 Cell Injection in Patients with Relapsed or Refractory CD7-Positive Natural Killer/T Cell Malignancies
Is NCT06732492 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies RD13-02 cell infusion for nk t-cell lymphoma.
Treatment: RD13-02 cell infusion — This is a single-arm, open-label, single-center, phase I study. The primary objective is to evaluate the safety of CD7 Chimeric Antigen Receptor-T(CAR-T) therapy for patients with CD7-positive relapsed or refractory natural killer/T cell lymphoma, and to evaluate the pharmacokinetics of CD7 CAR-T in patients。
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Multiple Myeloma
Myelodysplastic Syndrome
Chronic Lymphocytic Leukemia
Biomarker criteria
Required: CD7 positive expression (positive)
CD7 positive expression
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: anticancer therapy
Exception: before CAR-T infusion
Subjects with some anticancer therapy before CAR-T infusion will be excluded.
Lab requirements
Blood counts
Bone marrow lymphoblasts ≥5% by morphologic evaluation at screening
Kidney function
Creatinine clearance (as estimated by Cockcroft Gault) ≥ 60 mL/min
Liver function
Serum alanine aminotransferase(ALT)/aspartate aminotransferase(AST) < 3×upper limit of normal, Total bilirubin < 1.5×upper limit of normal or ≤1.5mg/dl
Cardiac function
Left ventricular ejection fraction ≥ 50%
Creatinine clearance (as estimated by Cockcroft Gault) ≥ 60 mL/min, Serum alanine aminotransferase(ALT)/aspartate aminotransferase(AST) < 3×upper limit of normal, Total bilirubin < 1.5×upper limit of normal or ≤1.5mg/dl; Left ventricular ejection fraction ≥ 50%.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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