OncoMatch/Clinical Trials/NCT06728072
Addition of Antibiotics to Upfront Treatment Regimen for Colorectal Cancer
Is NCT06728072 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Standard of Care Chemotherapy + Metronidazole, ciprofloxacin, aspirin for colorectal cancer.
Treatment: Standard of Care Chemotherapy + Metronidazole, ciprofloxacin, aspirin — This is a 2-arm, noncomparative phase 2 trial designed to evaluate treatment outcomes with or without the addition of ciprofloxacin, metronidazole, and aspirin to first-line chemotherapy for patients with stage IV colorectal cancer (CRC).
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Colorectal Cancer
Disease stage
Required: Stage IV
Metastatic disease required
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: antibiotics
Exception: prophylactic antibiotics at time of surgery allowed
Full course of antibiotics in the 30 days before chemotherapy start Note: Full course is defined as ≥5 doses with an intent to treat a defined infection. Use of antibiotics intended for prophylaxis at the time of surgery is allowed
Lab requirements
Blood counts
ANC ≥1,500 cells/μL; Platelet count ≥100,000 cells/μL; Hemoglobin ≥8 g/dL (transfusion/intervention allowed to achieve threshold)
Kidney function
Serum creatinine ≤1.5 x ULN or calculated creatinine clearance ≥40 mL/min using the Cockcroft-Gault equation
Liver function
AST and ALT ≤2.5 × ULN; if liver metastases: AST and ALT ≤5 × ULN
Cardiac function
Corrected QT interval (QTc) ≤480 on baseline ECG
ANC ≥1,500 cells/μL; Platelet count ≥100,000 cells/μL; Hemoglobin ≥8 g/dL Note: The use of transfusion or other intervention to achieve hemoglobin ≥8 g/dL is acceptable. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 × upper limit of normal (ULN) Note: Patients with documented liver metastases: AST and ALT ≤5 × ULN; Serum creatinine ≤1.5 x ULN or calculated creatinine clearance ≥40 mL/min using the Cockcroft-Gault equation; Corrected QT interval (QTc) >480 on baseline ECG [excluded]
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Virginia Commonwealth University · Richmond, Virginia
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT06728072 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
What disease stage is eligible?
Stage IV is required (metastatic disease required).
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages