OncoMatch/Clinical Trials/NCT06728072
Addition of Antibiotics to Upfront Treatment Regimen for Colorectal Cancer
Is NCT06728072 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Standard of Care Chemotherapy + Metronidazole, ciprofloxacin, aspirin for colorectal cancer.
Treatment: Standard of Care Chemotherapy + Metronidazole, ciprofloxacin, aspirin — This is a 2-arm, noncomparative phase 2 trial designed to evaluate treatment outcomes with or without the addition of ciprofloxacin, metronidazole, and aspirin to first-line chemotherapy for patients with stage IV colorectal cancer (CRC).
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Disease stage
Required: Stage IV
Metastatic disease required
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: antibiotics
Exception: prophylactic antibiotics at time of surgery allowed
Full course of antibiotics in the 30 days before chemotherapy start Note: Full course is defined as ≥5 doses with an intent to treat a defined infection. Use of antibiotics intended for prophylaxis at the time of surgery is allowed
Lab requirements
Blood counts
ANC ≥1,500 cells/μL; Platelet count ≥100,000 cells/μL; Hemoglobin ≥8 g/dL (transfusion/intervention allowed to achieve threshold)
Kidney function
Serum creatinine ≤1.5 x ULN or calculated creatinine clearance ≥40 mL/min using the Cockcroft-Gault equation
Liver function
AST and ALT ≤2.5 × ULN; if liver metastases: AST and ALT ≤5 × ULN
Cardiac function
Corrected QT interval (QTc) ≤480 on baseline ECG
ANC ≥1,500 cells/μL; Platelet count ≥100,000 cells/μL; Hemoglobin ≥8 g/dL Note: The use of transfusion or other intervention to achieve hemoglobin ≥8 g/dL is acceptable. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 × upper limit of normal (ULN) Note: Patients with documented liver metastases: AST and ALT ≤5 × ULN; Serum creatinine ≤1.5 x ULN or calculated creatinine clearance ≥40 mL/min using the Cockcroft-Gault equation; Corrected QT interval (QTc) >480 on baseline ECG [excluded]
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Virginia Commonwealth University · Richmond, Virginia
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