OncoMatch/Clinical Trials/NCT06719700
Concurrent Chemoradiotherapy Combined With Toripalimab and Surufatinib in the Treatment of Limited-Stage Small Cell Lung Cancer
Is NCT06719700 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Chemotherapy and Immunotherapy for toripalimab.
Treatment: Chemotherapy · Immunotherapy · Angio-immuno kinase inhibitor · Consolidation Therapy with Toripalimab and Surufatinib — Based on the preclinical rationale for combining surufatinib with immunotherapy, and the clinical efficacy observed with surufatinib in extensive-stage small cell lung cancer (ES-SCLC), the investigators hypothesize that incorporating surufatinib into the ADRIATIC regimen could further enhance survival in LS-SCLC. To evaluate this approach, the investigators plan to conduct a single-arm Phase II study to explore the safety and efficacy of concurrent chemoradiotherapy combined with toripalimab and surufatinib in treating LS-SCLC.
Check if I qualifyExtracted eligibility criteria
Cancer type
Small Cell Lung Cancer
Disease stage
Required: Stage I, II, III
Performance status
WHO 0–1
Prior therapy
Cannot have received: anti-PD-1 therapy
Previous Anti-PD-1/PD-L1 Therapy: Prior use of any anti-PD-1 or anti-PD-L1 antibodies.
Lab requirements
Blood counts
Absolute neutrophil count ≥1.5 × 10⁹/L. Platelet count ≥100 × 10⁹/L. Hemoglobin ≥9.0 g/dL.
Kidney function
Calculated creatinine clearance ≥50 mL/min using the Cockcroft-Gault formula.
Liver function
Serum bilirubin ≤1.5 × ULN. AST and ALT ≤2.5 × ULN.
Cardiac function
QTc interval (corrected by Bazett's formula) ≤470 ms, calculated from three ECG measurements.
Pulmonary Function: FEV1 ≥800 mL. Absolute neutrophil count ≥1.5 × 10⁹/L. Platelet count ≥100 × 10⁹/L. Hemoglobin ≥9.0 g/dL. Renal Function: Calculated creatinine clearance ≥50 mL/min using the Cockcroft-Gault formula. Serum bilirubin ≤1.5 × upper limit of normal (ULN). AST and ALT ≤2.5 × ULN. QTc interval (corrected by Bazett's formula) >470 ms, calculated from three ECG measurements [excluded].
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify