OncoMatch/Clinical Trials/NCT06712316
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
Is NCT06712316 recruiting? Yes, currently enrolling (May 2026). This Phase 2/3 trial studies multiple treatments for non-small cell lung cancer.
Treatment: Pumitamig · Pembrolizumab · Carboplatin · Pemetrexed · Paclitaxel — This is a Phase 2/3, multisite, randomized, open-label study in participants with first-line non-small cell lung cancer (NSCLC). This study includes two substudies (substudy A and substudy B) that will recruit participants according to histological subtypes due to differences in chemotherapy choice for standard-of-care and type of NSCLC.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Disease stage
Required: Stage IIIB, IIIC, IV
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: platinum-based chemotherapy
Previous chemotherapy (platinum-based) ... for treating NSCLC in either neo-adjuvant/adjuvant or locally advanced/metastatic setting
Cannot have received: anti-PD-1 therapy
Previous ... PD(L)-1 for treating NSCLC in either neo-adjuvant/adjuvant or locally advanced/metastatic setting
Cannot have received: anti-VEGF monoclonal antibody
prior treatment with anti-VEGF monoclonal antibody
Cannot have received: PD(L)-1/VEGF bispecific antibody
prior treatment with ... PD(L)-1/VEGF bispecific antibody
Lab requirements
Blood counts
Kidney function
Liver function
Adequate organ function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Alaska Oncology and Hematology, LLC · Anchorage, Alaska
- Clermont Oncology Center · Clermont, Florida
- Cleveland Clinic Florida - Martin North Hospital · Stuart, Florida
- H. Lee Moffit Cancer center and research institute · Tampa, Florida
- Cleveland Clinic Weston Hospital · Weston, Florida
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify