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OncoMatch/Clinical Trials/NCT06710756

Lead-212 PSV359 Therapy for Patients With Solid Tumors

Is NCT06710756 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1/2 trial studies multiple treatments including [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 for pancreatic ductal adenocarcinoma.

Phase 1/2RecruitingPerspective TherapeuticsNCT06710756Data as of Jun 2026

Treatment: [203Pb]Pb-PSV359 · [212Pb]Pb-PSV359Phase I/IIa image-guided, alpha-particle therapy study of \[203Pb\]Pb-PSV359 and \[212Pb\]Pb-PSV359 in patients with solid tumors that are known to be Fibroblast Activation Protein (FAP)-positive.

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Extracted eligibility criteria

Treatments studied

Other

[203Pb]Pb-PSV359[212Pb]Pb-PSV359

Cancer type

Pancreatic Cancer

Gastric Cancer

Esophageal Carcinoma

Colorectal Cancer

Ovarian Cancer

Head and Neck Squamous Cell Carcinoma

Sarcoma

Mesothelioma

Performance status

ECOG 0–1(Restricted strenuous activity)

Demographics

Ages ≤ 90

Prior therapy

Cannot have received: systemic anticancer therapy

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Saint Louis University · St Louis, Missouri
  • Nebraska Cancer Specialists · Omaha, Nebraska
  • University of Pittsburgh Medical Center · Pittsburgh, Pennsylvania

Showing up to 5 US sites.

See all sites on ClinicalTrials.gov →

Frequently asked questions

Is NCT06710756 currently recruiting?

Yes, this trial is currently recruiting patients.

Are there prior therapy exclusions?

Yes. Prior systemic anticancer therapy disqualifies patients from enrollment.

Is there an age limit?

Yes. Patients must be 90 years or younger.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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