OncoMatch/Clinical Trials/NCT06701812
Digoxin Medulloblastoma Study
Is NCT06701812 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Digoxin for medulloblastoma.
Treatment: Digoxin — The purpose of this study is to evaluate the efficacy of digoxin in treating relapsed non-SHH, non-WNT medulloblastoma in pediatric and young adult patients.
Check if I qualifyExtracted eligibility criteria
Cancer type
Glioblastoma
Prior therapy
Must have received: chemotherapy
Patients must have received at least one prior course of chemotherapy for their medulloblastoma
Must have received: irradiation
They must also have received irradiation
Cannot have received: digoxin (digoxin)
Exception: Exposure to digoxin therapy prior to initial diagnosis of medulloblastoma is allowed
Participants taking digoxin for any reason during treatment for initial diagnosis of medulloblastoma or relapse are ineligible. Exposure to digoxin therapy prior to initial diagnosis of medulloblastoma is allowed.
Lab requirements
Blood counts
normal organ and marrow function required
Kidney function
normal organ and marrow function required
Liver function
normal organ and marrow function required
Cardiac function
No evidence of Wolff-Parkinson-White syndrome or high-grade AV block on ECG; no evidence of hypertrophic obstructive cardiomyopathy on echo; no serious or inadequately controlled cardiac arrhythmias
Patients must have normal organ and marrow function. Patient has no evidence of Wolff-Parkinson-White syndrome or high-grade AV block (form of second-degree heart block) on screening ECG. Patient has no evidence of hypertrophic obstructive cardiomyopathy on screening echo. Patients with serious or inadequately controlled cardiac arrhythmias, including baseline ectopy, ventricular tachycardia, frequent premature ventricular contractions (PVCs), or symptomatic sinus bradycardia are excluded from the study.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Alabama at Birmingham Children's of Alabama · Birmingham, Alabama
- Arkansas Childrens Hospital · Little Rock, Arkansas
- Connecticut Children's Medical Center · Hartford, Connecticut
- Children's National Medical Center · Washington D.C., District of Columbia
- Nemours Jacksonville · Jacksonville, Florida
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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