OncoMatch/Clinical Trials/NCT06698822
A Phase 2 Trial to Assess Safety and Efficacy of Tofacitinib 2% Cream in the Treatment of Cutaneous T-cell Lymphoma (CTCL), Stages IA, IB, and IIA
Is NCT06698822 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies tofacitinib 2% cream for cutaneous t-cell lymphoma.
Treatment: tofacitinib 2% cream — To study the safety and effectiveness of tofacitinib 2% cream in treating early-stage CTCL.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Disease stage
Required: Stage IA, IB, IIA
Excluded: Stage IIB, IIIA, IIIB, IV
stage IA, IB, or IIA; For stage IIA, only participants with a classification of N0 (no clinically abnormal peripheral lymph nodes) or N1 (clinically abnormal lymph node(s) histopathology Dutch grade 1 or NCI LN0-2) can be enrolled; Participants must be B0 (absence of significant blood involvement: .5% of peripheral blood lymphocytes of <250/mcL are atypical); History of Stage IIB or greater CTCL, or stage IIA CTCL with history of stage N2 (Dutch Grade 2 or NCI LN3 or greater), or with >5% circulating Sezary cells
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: standard therapy
at least 2 distinct lesions that have either failed or recurred despite treatment with 1 previous standard therapy
Cannot have received: Total Skin Electron Beam Therapy
In the past 12 weeks: Total Skin Electron Beam Therapy (TSEBT)
Cannot have received: topical imiquimod
In the past 8 weeks: topical imiquimod
Cannot have received: topical corticosteroids
In the past 4 weeks: topical corticosteroids
Cannot have received: topical chemotherapy
In the past 4 weeks: topical chemotherapy
Cannot have received: topical retinoids
In the past 4 weeks: topical retinoids
Cannot have received: local radiation therapy
In the past 4 weeks: local radiation therapy
Cannot have received: UVB therapy
In the past 4 weeks: UVB therapy
Cannot have received: PUVA
In the past 4 weeks: PUVA
Cannot have received: photopheresis
In the past 4 weeks: photopheresis
Cannot have received: systemic retinoids
In the past 4 weeks: systemic retinoids
Cannot have received: systemic corticosteroids
In the past 4 weeks: systemic corticosteroids
Cannot have received: interferon inducers
In the past 4 weeks: interferon inducers
Cannot have received: systemic chemotherapeutic agents
In the past 4 weeks: systemic chemotherapeutic agents
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- MD Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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