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OncoMatch/Clinical Trials/NCT06698822

A Phase 2 Trial to Assess Safety and Efficacy of Tofacitinib 2% Cream in the Treatment of Cutaneous T-cell Lymphoma (CTCL), Stages IA, IB, and IIA

Is NCT06698822 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies tofacitinib 2% cream for cutaneous t-cell lymphoma.

Phase 2RecruitingM.D. Anderson Cancer CenterNCT06698822Data as of May 2026

Treatment: tofacitinib 2% creamTo study the safety and effectiveness of tofacitinib 2% cream in treating early-stage CTCL.

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Extracted eligibility criteria

Cancer type

Non-Hodgkin Lymphoma

Disease stage

Required: Stage IA, IB, IIA

Excluded: Stage IIB, IIIA, IIIB, IV

stage IA, IB, or IIA; For stage IIA, only participants with a classification of N0 (no clinically abnormal peripheral lymph nodes) or N1 (clinically abnormal lymph node(s) histopathology Dutch grade 1 or NCI LN0-2) can be enrolled; Participants must be B0 (absence of significant blood involvement: .5% of peripheral blood lymphocytes of <250/mcL are atypical); History of Stage IIB or greater CTCL, or stage IIA CTCL with history of stage N2 (Dutch Grade 2 or NCI LN3 or greater), or with >5% circulating Sezary cells

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Min 1 prior line

Must have received: standard therapy

at least 2 distinct lesions that have either failed or recurred despite treatment with 1 previous standard therapy

Cannot have received: Total Skin Electron Beam Therapy

In the past 12 weeks: Total Skin Electron Beam Therapy (TSEBT)

Cannot have received: topical imiquimod

In the past 8 weeks: topical imiquimod

Cannot have received: topical corticosteroids

In the past 4 weeks: topical corticosteroids

Cannot have received: topical chemotherapy

In the past 4 weeks: topical chemotherapy

Cannot have received: topical retinoids

In the past 4 weeks: topical retinoids

Cannot have received: local radiation therapy

In the past 4 weeks: local radiation therapy

Cannot have received: UVB therapy

In the past 4 weeks: UVB therapy

Cannot have received: PUVA

In the past 4 weeks: PUVA

Cannot have received: photopheresis

In the past 4 weeks: photopheresis

Cannot have received: systemic retinoids

In the past 4 weeks: systemic retinoids

Cannot have received: systemic corticosteroids

In the past 4 weeks: systemic corticosteroids

Cannot have received: interferon inducers

In the past 4 weeks: interferon inducers

Cannot have received: systemic chemotherapeutic agents

In the past 4 weeks: systemic chemotherapeutic agents

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • MD Anderson Cancer Center · Houston, Texas

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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