OncoMatch/Clinical Trials/NCT06698822
A Phase 2 Trial to Assess Safety and Efficacy of Tofacitinib 2% Cream in the Treatment of Cutaneous T-cell Lymphoma (CTCL), Stages IA, IB, and IIA
Is NCT06698822 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies tofacitinib 2% cream for cutaneous t-cell lymphoma.
Treatment: tofacitinib 2% cream — To study the safety and effectiveness of tofacitinib 2% cream in treating early-stage CTCL.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Non-Hodgkin Lymphoma
Disease stage
Required: Stage IA, IB, IIA
Excluded: Stage IIB, IIIA, IIIB, IV
stage IA, IB, or IIA; For stage IIA, only participants with a classification of N0 (no clinically abnormal peripheral lymph nodes) or N1 (clinically abnormal lymph node(s) histopathology Dutch grade 1 or NCI LN0-2) can be enrolled; Participants must be B0 (absence of significant blood involvement: .5% of peripheral blood lymphocytes of <250/mcL are atypical); History of Stage IIB or greater CTCL, or stage IIA CTCL with history of stage N2 (Dutch Grade 2 or NCI LN3 or greater), or with >5% circulating Sezary cells
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: standard therapy
at least 2 distinct lesions that have either failed or recurred despite treatment with 1 previous standard therapy
Cannot have received: Total Skin Electron Beam Therapy
In the past 12 weeks: Total Skin Electron Beam Therapy (TSEBT)
Cannot have received: topical imiquimod
In the past 8 weeks: topical imiquimod
Cannot have received: topical corticosteroids
In the past 4 weeks: topical corticosteroids
Cannot have received: topical chemotherapy
In the past 4 weeks: topical chemotherapy
Cannot have received: topical retinoids
In the past 4 weeks: topical retinoids
Cannot have received: local radiation therapy
In the past 4 weeks: local radiation therapy
Cannot have received: UVB therapy
In the past 4 weeks: UVB therapy
Cannot have received: PUVA
In the past 4 weeks: PUVA
Cannot have received: photopheresis
In the past 4 weeks: photopheresis
Cannot have received: systemic retinoids
In the past 4 weeks: systemic retinoids
Cannot have received: systemic corticosteroids
In the past 4 weeks: systemic corticosteroids
Cannot have received: interferon inducers
In the past 4 weeks: interferon inducers
Cannot have received: systemic chemotherapeutic agents
In the past 4 weeks: systemic chemotherapeutic agents
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- MD Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT06698822 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior Total Skin Electron Beam Therapy, topical imiquimod, topical corticosteroids disqualifies patients from enrollment.
What disease stage is eligible?
Stage IA or IB or IIA is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages