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OncoMatch/Clinical Trials/NCT06698822

A Phase 2 Trial to Assess Safety and Efficacy of Tofacitinib 2% Cream in the Treatment of Cutaneous T-cell Lymphoma (CTCL), Stages IA, IB, and IIA

Is NCT06698822 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies tofacitinib 2% cream for cutaneous t-cell lymphoma.

Phase 2RecruitingM.D. Anderson Cancer CenterNCT06698822Data as of Jun 2026

Treatment: tofacitinib 2% creamTo study the safety and effectiveness of tofacitinib 2% cream in treating early-stage CTCL.

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Extracted eligibility criteria

Treatments studied

Other

tofacitinib 2% cream

Cancer type

Non-Hodgkin Lymphoma

Disease stage

Required: Stage IA, IB, IIA

Excluded: Stage IIB, IIIA, IIIB, IV

stage IA, IB, or IIA; For stage IIA, only participants with a classification of N0 (no clinically abnormal peripheral lymph nodes) or N1 (clinically abnormal lymph node(s) histopathology Dutch grade 1 or NCI LN0-2) can be enrolled; Participants must be B0 (absence of significant blood involvement: .5% of peripheral blood lymphocytes of <250/mcL are atypical); History of Stage IIB or greater CTCL, or stage IIA CTCL with history of stage N2 (Dutch Grade 2 or NCI LN3 or greater), or with >5% circulating Sezary cells

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Min 1 prior line

Must have received: standard therapy

at least 2 distinct lesions that have either failed or recurred despite treatment with 1 previous standard therapy

Cannot have received: Total Skin Electron Beam Therapy

In the past 12 weeks: Total Skin Electron Beam Therapy (TSEBT)

Cannot have received: topical imiquimod

In the past 8 weeks: topical imiquimod

Cannot have received: topical corticosteroids

In the past 4 weeks: topical corticosteroids

Cannot have received: topical chemotherapy

In the past 4 weeks: topical chemotherapy

Cannot have received: topical retinoids

In the past 4 weeks: topical retinoids

Cannot have received: local radiation therapy

In the past 4 weeks: local radiation therapy

Cannot have received: UVB therapy

In the past 4 weeks: UVB therapy

Cannot have received: PUVA

In the past 4 weeks: PUVA

Cannot have received: photopheresis

In the past 4 weeks: photopheresis

Cannot have received: systemic retinoids

In the past 4 weeks: systemic retinoids

Cannot have received: systemic corticosteroids

In the past 4 weeks: systemic corticosteroids

Cannot have received: interferon inducers

In the past 4 weeks: interferon inducers

Cannot have received: systemic chemotherapeutic agents

In the past 4 weeks: systemic chemotherapeutic agents

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • MD Anderson Cancer Center · Houston, Texas

Showing up to 5 US sites.

See all sites on ClinicalTrials.gov →

Frequently asked questions

Is NCT06698822 currently recruiting?

Yes, this trial is currently recruiting patients.

Are there prior therapy exclusions?

Yes. Prior Total Skin Electron Beam Therapy, topical imiquimod, topical corticosteroids disqualifies patients from enrollment.

What disease stage is eligible?

Stage IA or IB or IIA is required.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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