OncoMatch/Clinical Trials/NCT06696768
Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer
Is NCT06696768 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments for metastatic colorectal adenocarcinoma.
Treatment: Bevacizumab · Emavusertib · Fluorouracil · Leucovorin Calcium · Oxaliplatin — This phase I trial studies the side effects and best dose of CA-4948 when given together with fluorouracil, leucovorin, oxaliplatin (FOLFOX) plus bevacizumab in treating patients with colorectal cancer that has spread from where it first started (primary site) to other places in the body (metastatic). CA-4948 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The chemotherapy drugs used in FOLFOX, fluorouracil and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Leucovorin is used with fluorouracil to treat colorectal cancer. Bevacizumab is in a class of medications called anti-angiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to the tumor. This may slow the growth and spread of the tumor. Giving CA-4948 with FOLFOX plus bevacizumab may be safe, tolerable and/or effective in treating patients with metastatic colorectal cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Biomarker criteria
Excluded: MSH2 deficient mismatch repair
Patients with high-frequency microsatellite instability (MSI-H) or deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR) colorectal cancer at pre-enrollment screening
Excluded: MSH6 deficient mismatch repair
Patients with high-frequency microsatellite instability (MSI-H) or deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR) colorectal cancer at pre-enrollment screening
Excluded: MLH1 deficient mismatch repair
Patients with high-frequency microsatellite instability (MSI-H) or deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR) colorectal cancer at pre-enrollment screening
Excluded: PMS2 deficient mismatch repair
Patients with high-frequency microsatellite instability (MSI-H) or deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR) colorectal cancer at pre-enrollment screening
Disease stage
Required: Stage III, IV (AJCC v8)
unresectable or metastatic measurable disease on imaging for Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 determination within 28 days of registration
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: chemotherapy (FOLFOX, FOLFIRI, FOLFOXIRI, bevacizumab)
Patients who have received prior treatment with any chemotherapy (either in the adjuvant or metastatic setting), including FOLFOX, fluorouracil/leucovorin/irinotecan (FOLFIRI), folinic acid/fluorouracil/oxaliplatin/irinotecan (FOLFOXIRI), or antiangiogenic agents such as bevacizumab and similar agents, are not eligible for this study
Lab requirements
Blood counts
Absolute neutrophil count ≥ 1,500/mcL; Platelets ≥ 75,000/mcL
Kidney function
eGFR ≥ 60 mL/min/1.73 m^2
Liver function
Total bilirubin ≤ 1.5 × institutional ULN; AST/ALT ≤ 3 × institutional ULN; for those with liver metastases, 5 × institutional ULN
Cardiac function
NYHA class II or better; QTcF ≤ 450ms
Absolute neutrophil count ≥ 1,500/mcL...Platelets ≥ 75,000/mcL...Total bilirubin ≤ 1.5 × institutional ULN...AST/ALT ≤ 3 × institutional ULN; for those with liver metastases, 5 × institutional ULN...eGFR ≥ 60 mL/min/1.73 m^2...CPK elevation at screening < grade 2 (CPK ≤ 2.5 x ULN)...NYHA class II or better...QTcF ( > 450ms) on screening ECG [excluded]
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- UF Health Cancer Institute - Gainesville · Gainesville, Florida
- Memorial Hospital East · Shiloh, Illinois
- University of Kansas Clinical Research Center · Fairway, Kansas
- University of Kansas Cancer Center · Kansas City, Kansas
- University of Kansas Hospital-Indian Creek Campus · Overland Park, Kansas
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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