OncoMatch

OncoMatch/Clinical Trials/NCT06673693

Tislelizumab Combined With SBRT for the Treatment of Head and Neck Squamous Cell Carcinoma

Is NCT06673693 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Tislelizumab for head and neck squamous cell carcinoma (hnscc).

Phase 2RecruitingSun Yat-sen UniversityNCT06673693Data as of May 2026

Treatment: TislelizumabExploring the efficacy and safety of Tislelizumab combined with stereotactic body radiation therapy (SBRT) as neoadjuvant treatment for locally advanced head and neck squamous cell carcinoma (HNSCC).

Check if I qualify

Extracted eligibility criteria

Cancer type

Head and Neck Squamous Cell Carcinoma

Disease stage

Required: Stage III, IVA, IVB

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: surgery

Exception: diagnostic biopsies of primary and regional lymph nodes

Patients previously treated with head and neck surgery were excluded from diagnostic biopsies of primary and regional lymph nodes

Cannot have received: chemotherapy

Previous chemotherapy for any reason

Cannot have received: radiation therapy

radiotherapy in the head and neck area

Cannot have received: molecular targeted drug therapy

molecular targeted drug therapy

Cannot have received: anti-PD-1 therapy

anti-PD-1, anti-PD-L1, anti-PD-L2 and other drugs or drugs acting on another irritating or co-inhibitory T cell receptor (such as CTLA-4, OX 40, CD137) treatment

Cannot have received: cell biotherapy

cell biotherapy

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

Check if I qualify