OncoMatch/Clinical Trials/NCT06647732
Zanubrutinib Plus Rituximab as Front-line Treatment for Mucosa-associated Lymphoid Tissue Lymphoma (MALT)
Is NCT06647732 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Zanubrutinib and Rituximab for mucosa-associated lymphoid tissue lymphoma (malt).
Treatment: Zanubrutinib · Rituximab — This is a prospective, single-arm, multicenter, phase II clinical trial to evaluate the efficacy and safety of Zanubrutinib in combination with Rituximab as a first-line treatment for patients with mucosa-associated lymphoid tissue (MALT) extranodal marginal zone lymphoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Disease stage
Required: Stage III, IV
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: systemic anti-lymphoma therapy
Exception: H. pylori eradication therapy in H. pylori-positive gastric MALT patients
No prior systemic anti-lymphoma therapy (except for H. pylori eradication therapy in H. pylori-positive gastric MALT patients)
Cannot have received: BTK inhibitor
Patients who have previously used BTK inhibitors
Cannot have received: CD20 monoclonal antibody therapy
Patients who have previously...received CD20 monoclonal antibody therapy
Cannot have received: allogeneic hematopoietic stem cell transplantation
Patients who have undergone allogeneic hematopoietic stem cell transplantation in the past
Cannot have received: anti-tumor therapy
Patients who have received anti-tumor therapy within 4 weeks prior to enrollment
Cannot have received: systemic corticosteroid
Patients who have received systemic corticosteroid treatment or other immunosuppressive therapy within 14 days prior to the start of study treatment
Cannot have received: immunosuppressive therapy
Patients who have received systemic corticosteroid treatment or other immunosuppressive therapy within 14 days prior to the start of study treatment
Lab requirements
Blood counts
adequate bone marrow function
Kidney function
adequate kidney function
Liver function
adequate liver function
Cardiac function
adequate cardiac function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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