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OncoMatch/Clinical Trials/NCT06647732

Zanubrutinib Plus Rituximab as Front-line Treatment for Mucosa-associated Lymphoid Tissue Lymphoma (MALT)

Is NCT06647732 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Zanubrutinib and Rituximab for mucosa-associated lymphoid tissue lymphoma (malt).

Phase 2RecruitingSun Yat-sen UniversityNCT06647732Data as of May 2026

Treatment: Zanubrutinib · RituximabThis is a prospective, single-arm, multicenter, phase II clinical trial to evaluate the efficacy and safety of Zanubrutinib in combination with Rituximab as a first-line treatment for patients with mucosa-associated lymphoid tissue (MALT) extranodal marginal zone lymphoma.

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Extracted eligibility criteria

Cancer type

Non-Hodgkin Lymphoma

Disease stage

Required: Stage III, IV

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: systemic anti-lymphoma therapy

Exception: H. pylori eradication therapy in H. pylori-positive gastric MALT patients

No prior systemic anti-lymphoma therapy (except for H. pylori eradication therapy in H. pylori-positive gastric MALT patients)

Cannot have received: BTK inhibitor

Patients who have previously used BTK inhibitors

Cannot have received: CD20 monoclonal antibody therapy

Patients who have previously...received CD20 monoclonal antibody therapy

Cannot have received: allogeneic hematopoietic stem cell transplantation

Patients who have undergone allogeneic hematopoietic stem cell transplantation in the past

Cannot have received: anti-tumor therapy

Patients who have received anti-tumor therapy within 4 weeks prior to enrollment

Cannot have received: systemic corticosteroid

Patients who have received systemic corticosteroid treatment or other immunosuppressive therapy within 14 days prior to the start of study treatment

Cannot have received: immunosuppressive therapy

Patients who have received systemic corticosteroid treatment or other immunosuppressive therapy within 14 days prior to the start of study treatment

Lab requirements

Blood counts

adequate bone marrow function

Kidney function

adequate kidney function

Liver function

adequate liver function

Cardiac function

adequate cardiac function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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