OncoMatch/Clinical Trials/NCT06640166
Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer Progressing on Encorafenib + Cetuximab.
Is NCT06640166 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies encorafenib + cetuximab + FOLFIRI for colorectal carcinoma.
Treatment: encorafenib + cetuximab + FOLFIRI — The aim of this study is to determine the activity of encorafenib plus cetuximab in combination with FOLFIRI in patients with BRAF V600E mutated metastatic colorectal cancer progressing on encorafenib plus cetuximab administered in second line.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Biomarker criteria
Required: BRAF v600e
Disease stage
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: BRAF inhibitor + anti-EGFR therapy (encorafenib, cetuximab) — second line
disease progression while on treatment with EC received in 2nd line setting
Lab requirements
Blood counts
ANC ≥ 1.5 × 10^9/L; Platelets ≥ 100 × 10^9/L; Hemoglobin ≥ 9.0 g/dL; transfusions allowed to achieve this (≤2 units RBC in prior 4 weeks)
Kidney function
serum creatinine ≤ 1.5 × ULN, or calculated by Cockroft-Gault formula, or directly measured creatinine clearance ≥ 50 mL/min at screening
Liver function
serum total bilirubin ≤ 1.5 × ULN; ALT and/or AST ≤ 2.5 × ULN, or ≤ 5 × ULN in presence of liver metastases
Cardiac function
QTcF ≤480 msec
Adequate bone marrow function at screening: ANC ≥ 1.5 × 10^9/L; Platelets ≥ 100 × 10^9/L; Hemoglobin ≥ 9.0 g/dL; transfusions allowed to achieve this. Adequate renal function at screening: serum creatinine ≤ 1.5 × ULN, or calculated by Cockroft-Gault formula, or directly measured creatinine clearance ≥ 50 mL/min at screening. Adequate hepatic function at screening: serum total bilirubin ≤ 1.5 × ULN; ALT and/or AST ≤ 2.5 × ULN, or ≤ 5 × ULN in presence of liver metastases. Adequate cardiac function: QTcF ≤480 msec.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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