OncoMatch/Clinical Trials/NCT06627738
Locally Advanced NSCLC Treated With Radiochemotherapy: Phase 2 Study on the Value of a Stereotactic Boost
Is NCT06627738 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for carcinoma, non-small-cell lung.
This is a monocentric, non-randomized, open-label, superiority phase II clinical investigation evaluating the efficacy of additional Cyberknife irradiation after a doublet of Platinum Salts-based chemotherapy and concomitant radiotherapy in patients with locally advanced non-small cell lung carcinoma (NSCLC), with an interim analysis.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Excluded: EGFR positive mutation
Positive EGFR mutation
Disease stage
Required: Stage III
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: platinum-based chemotherapy — induction (2 cycles) and concomitant (at least 2 cycles) with radiotherapy
2 cycles of induction chemotherapy (platinium-based doublet) and then at least 40 Gy of irradiation in combination with at least 2 cycles of concomitant chemotherapy (platinium-based doublet)
Must have received: radiation therapy — at least 40 Gy, with chemotherapy
at least 40 Gy of irradiation in combination with at least 2 cycles of concomitant chemotherapy (platinium-based doublet)
Lab requirements
Cardiac function
No exercise-induced dyspnea associated with heart failure ≥ NYHA III; no coronary syndrome or heart failure in last 3 months
Exercise-induced dyspnea associated with heart failure equal to or greater than stage III of the New York Heart Association (NYHA) classification [excluded]; Coronary syndrome or heart failure in the last three months [excluded]
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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