OncoMatch/Clinical Trials/NCT06620848
A Study of HRS-4642 Monotherapy or in Combination With Adebrelimab in the Treatment of Advanced Biliary Tract Tumors.
Is NCT06620848 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies multiple treatments including HRS-4642 monotherapy and HRS-4642 and adebrelimab combination therapy for biliary tract cancer.
Treatment: HRS-4642 monotherapy · HRS-4642 and adebrelimab combination therapy — The study was designed to evaluate the efficacy and safety of HRS-4642 monotherapy or in combination with adebrelimab in the treatment of advanced biliary tract tumor patients.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Cholangiocarcinoma
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Must have received: systemic therapy
progression or intolerance for one line of systemic therapy
Must have received: gemcitabine-based chemotherapy (gemcitabine) — adjuvant or neoadjuvant
adjuvant therapy or neoadjuvant therapy must include gemcitabine-based chemotherapy
Cannot have received: anti-tumor chemotherapy
Exception: within 4 weeks before the study drug administration
Prior anti-tumor chemotherapy within 4 weeks before the study drug administration
Cannot have received: small molecular targeted drugs
Exception: with a half-life of less than 5 or 7 days from the first medication
Small molecular targeted drugs (including oral targeted drugs for other clinical trials) with a half-life of less than 5 or 7 days from the first medication
Lab requirements
Blood counts
Kidney function
Liver function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06620848 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior anti-tumor chemotherapy, small molecular targeted drugs disqualifies patients from enrollment.
Is there an age limit?
Yes. Patients must be 75 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages