OncoMatch/Clinical Trials/NCT06618287
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Is NCT06618287 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments for lung cancer.
Treatment: BMS-986507 · Osimertinib · Pembrolizumab · Nivolumab · Pumitamig — The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Breast Carcinoma
Biomarker criteria
Required: EGFR exon 19 deletion
EGFR exon 19 deletion
Required: EGFR L858R mutation in exon 21
L858R mutation in exon 21
Required: EGFR wild-type
Participants with known mutations in EGFR will be excluded (Group A,B and E).
Allowed: EGFR T790M in exon 20
which may include T790M in exon 20
Allowed: EGFR L861Q in exon 21
other EGFR mutations (including but not limited to, exon 21 L861Q, exon 18 G719X, and exon 20 S768I mutations, etc.) will also be allowed
Allowed: EGFR G719X in exon 18
other EGFR mutations (including but not limited to, exon 21 L861Q, exon 18 G719X, and exon 20 S768I mutations, etc.) will also be allowed
Allowed: EGFR S768I in exon 20
other EGFR mutations (including but not limited to, exon 21 L861Q, exon 18 G719X, and exon 20 S768I mutations, etc.) will also be allowed
Performance status
ECOG 0–1(Restricted strenuous activity)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Alabama at Birmingham · Birmingham, Alabama
- University of Miami Hospital and Clinics, Sylvester Cancer Center · Miami, Florida
- Local Institution - 0125 · Maywood, Illinois
- Local Institution - 0065 · Iowa City, Iowa
- John Theurer Cancer Center at Hackensack University Medical Center · Hackensack, New Jersey
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify