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OncoMatch/Clinical Trials/NCT06618287

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

Is NCT06618287 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments for lung cancer.

Phase 1/2RecruitingBristol-Myers SquibbNCT06618287Data as of May 2026

Treatment: BMS-986507 · Osimertinib · Pembrolizumab · Nivolumab · PumitamigThe purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.

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Extracted eligibility criteria

Cancer type

Non-Small Cell Lung Carcinoma

Breast Carcinoma

Biomarker criteria

Required: EGFR exon 19 deletion

EGFR exon 19 deletion

Required: EGFR L858R mutation in exon 21

L858R mutation in exon 21

Required: EGFR wild-type

Participants with known mutations in EGFR will be excluded (Group A,B and E).

Allowed: EGFR T790M in exon 20

which may include T790M in exon 20

Allowed: EGFR L861Q in exon 21

other EGFR mutations (including but not limited to, exon 21 L861Q, exon 18 G719X, and exon 20 S768I mutations, etc.) will also be allowed

Allowed: EGFR G719X in exon 18

other EGFR mutations (including but not limited to, exon 21 L861Q, exon 18 G719X, and exon 20 S768I mutations, etc.) will also be allowed

Allowed: EGFR S768I in exon 20

other EGFR mutations (including but not limited to, exon 21 L861Q, exon 18 G719X, and exon 20 S768I mutations, etc.) will also be allowed

Performance status

ECOG 0–1(Restricted strenuous activity)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • University of Alabama at Birmingham · Birmingham, Alabama
  • University of Miami Hospital and Clinics, Sylvester Cancer Center · Miami, Florida
  • Local Institution - 0125 · Maywood, Illinois
  • Local Institution - 0065 · Iowa City, Iowa
  • John Theurer Cancer Center at Hackensack University Medical Center · Hackensack, New Jersey

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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